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10.7150/ijbs.19603 http://scihub22266oqcxt.onion/10.7150/ijbs.19603 C5485632!5485632!28656002     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Biol+Sci 2017 ; 13 (6): 772-81 Nephropedia Template TP {{tp|p=28656002|t=2017. Angiomotin Family Members: Oncogenes or Tumor Suppressors?|pdf=|usr=}}{{28656002}} gab.com Text Angiomotin Family Members: Oncogenes or Tumor Suppressors JO: Int J Biol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28656002 #FOAvip Angiomotin (Amot) family contains three members: Amot (p80 and p130 isoforms), Amot-like protein 1 (Amotl1), and Amot-like protein 2 (Amotl2). Amot proteins play an important role in tube formation and migration of endothelial cells and the regulation of tight junctions, polarity, and epithelial-mesenchymal transition in epithelial cells. Moreover, these proteins regulate the proliferation and migration of cancer cells. In most cancers, Amot family members promote the proliferation and invasion of cancer cells, including breast cancer, osteosarcoma, colon cancer, prostate cancer, head and neck squamous cell carcinoma, cervical cancer, liver cancer, and renal cell cancer. However, in glioblastoma, ovarian cancer, and lung cancer, Amot inhibits the growth of cancer cells. In addition, there are controversies on the regulation of Yes-associated protein (YAP) by Amot. Amot promotes either the internalization of YAP into the nucleus or the retention of YAP in the cytoplasm of different cell types. Moreover, Amot regulates the AMPK, mTOR, Wnt, and MAPK signaling pathways. However, it is unclear whether Amot is an oncogene or a tumor suppressor gene in different cellular processes. This review focuses on the multifunctional roles of Amot in cancers. Twit Text FOAVip Angiomotin Family Members: Oncogenes or Tumor Suppressors ????Int J Biol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28656002 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28656002 #FOAvip English Wikipedia <ref>{{Cite pmid|28656002}}</ref> Angiomotin Family Members: Oncogenes or Tumor Suppressors? #MMPMID28656002 Lv M; Shen Y; Yang J; Li S; Wang B; Chen Z; Li P; Liu P; Yang J Int J Biol Sci 2017[]; 13 (6): 772-81 PMID28656002show ga Angiomotin (Amot) family contains three members: Amot (p80 and p130 isoforms), Amot-like protein 1 (Amotl1), and Amot-like protein 2 (Amotl2). Amot proteins play an important role in tube formation and migration of endothelial cells and the regulation of tight junctions, polarity, and epithelial-mesenchymal transition in epithelial cells. Moreover, these proteins regulate the proliferation and migration of cancer cells. In most cancers, Amot family members promote the proliferation and invasion of cancer cells, including breast cancer, osteosarcoma, colon cancer, prostate cancer, head and neck squamous cell carcinoma, cervical cancer, liver cancer, and renal cell cancer. However, in glioblastoma, ovarian cancer, and lung cancer, Amot inhibits the growth of cancer cells. In addition, there are controversies on the regulation of Yes-associated protein (YAP) by Amot. Amot promotes either the internalization of YAP into the nucleus or the retention of YAP in the cytoplasm of different cell types. Moreover, Amot regulates the AMPK, mTOR, Wnt, and MAPK signaling pathways. However, it is unclear whether Amot is an oncogene or a tumor suppressor gene in different cellular processes. This review focuses on the multifunctional roles of Amot in cancers. äAngiomotin Family Members: Oncogenes or Tumor Suppressors?(epmc).pdf DeepDyve Pubget Overpricing