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10.3390/genes8060158 http://scihub22266oqcxt.onion/10.3390/genes8060158 C5485522!5485522!28590415     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Genes+(Basel) 2017 ; 8 (6): ä Nephropedia Template TP {{tp|p=28590415|t=2017. The Dual Roles of MYC in Genomic Instability and Cancer Chemoresistance |pdf=|usr=}}{{28590415}} gab.com Text The Dual Roles of MYC in Genomic Instability and Cancer Chemoresistance JO: Genes (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=28590415 #FOAvip Cancer is associated with genomic instability and aging. Genomic instability stimulates tumorigenesis, whereas deregulation of oncogenes accelerates DNA replication and increases genomic instability. It is therefore reasonable to assume a positive feedback loop between genomic instability and oncogenic stress. Consistent with this premise, overexpression of the MYC transcription factor increases the phosphorylation of serine 139 in histone H2AX (member X of the core histone H2A family), which forms so-called ?H2AX, the most widely recognized surrogate biomarker of double-stranded DNA breaks (DSBs). Paradoxically, oncogenic MYC can also promote the resistance of cancer cells to chemotherapeutic DNA-damaging agents such as cisplatin, clearly implying an antagonistic role of MYC in genomic instability. In this review, we summarize the underlying mechanisms of the conflicting functions of MYC in genomic instability and discuss when and how the oncoprotein exerts the contradictory roles in induction of DSBs and protection of cancer-cell genomes. Twit Text FOAVip The Dual Roles of MYC in Genomic Instability and Cancer Chemoresistance ????Genes (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=28590415 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28590415 #FOAvip English Wikipedia <ref>{{Cite pmid|28590415}}</ref> The Dual Roles of MYC in Genomic Instability and Cancer Chemoresistance #MMPMID28590415 Kumari A; Folk WP; Sakamuro D Genes (Basel) 2017[Jun]; 8 (6): ä PMID28590415show ga Cancer is associated with genomic instability and aging. Genomic instability stimulates tumorigenesis, whereas deregulation of oncogenes accelerates DNA replication and increases genomic instability. It is therefore reasonable to assume a positive feedback loop between genomic instability and oncogenic stress. Consistent with this premise, overexpression of the MYC transcription factor increases the phosphorylation of serine 139 in histone H2AX (member X of the core histone H2A family), which forms so-called ?H2AX, the most widely recognized surrogate biomarker of double-stranded DNA breaks (DSBs). Paradoxically, oncogenic MYC can also promote the resistance of cancer cells to chemotherapeutic DNA-damaging agents such as cisplatin, clearly implying an antagonistic role of MYC in genomic instability. In this review, we summarize the underlying mechanisms of the conflicting functions of MYC in genomic instability and discuss when and how the oncoprotein exerts the contradictory roles in induction of DSBs and protection of cancer-cell genomes. äThe Dual Roles of MYC in Genomic Instability and Cancer Chemoresistanc(epmc).pdf DeepDyve Pubget Overpricing