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10.3390/genes8060157 http://scihub22266oqcxt.onion/10.3390/genes8060157 C5485521!5485521!28587229     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Genes+(Basel) 2017 ; 8 (6): ä Nephropedia Template TP {{tp|p=28587229|t=2017. Ataxin-2: From RNA Control to Human Health and Disease |pdf=|usr=}}{{28587229}} gab.com Text Ataxin-2: From RNA Control to Human Health and Disease JO: Genes (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=28587229 #FOAvip RNA-binding proteins play fundamental roles in the regulation of molecular processes critical to cellular and organismal homeostasis. Recent studies have identified the RNA-binding protein Ataxin-2 as a genetic determinant or risk factor for various diseases including spinocerebellar ataxia type II (SCA2) and amyotrophic lateral sclerosis (ALS), amongst others. Here, we first discuss the increasingly wide-ranging molecular functions of Ataxin-2, from the regulation of RNA stability and translation to the repression of deleterious accumulation of the RNA-DNA hybrid-harbouring R-loop structures. We also highlight the broader physiological roles of Ataxin-2 such as in the regulation of cellular metabolism and circadian rhythms. Finally, we discuss insight from clinically focused studies to shed light on the impact of molecular and physiological roles of Ataxin-2 in various human diseases. We anticipate that deciphering the fundamental functions of Ataxin-2 will uncover unique approaches to help cure or control debilitating and lethal human diseases. Twit Text FOAVip Ataxin-2: From RNA Control to Human Health and Disease ????Genes (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=28587229 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28587229 #FOAvip English Wikipedia <ref>{{Cite pmid|28587229}}</ref> Ataxin-2: From RNA Control to Human Health and Disease #MMPMID28587229 Ostrowski LA; Hall AC; Mekhail K Genes (Basel) 2017[Jun]; 8 (6): ä PMID28587229show ga RNA-binding proteins play fundamental roles in the regulation of molecular processes critical to cellular and organismal homeostasis. Recent studies have identified the RNA-binding protein Ataxin-2 as a genetic determinant or risk factor for various diseases including spinocerebellar ataxia type II (SCA2) and amyotrophic lateral sclerosis (ALS), amongst others. Here, we first discuss the increasingly wide-ranging molecular functions of Ataxin-2, from the regulation of RNA stability and translation to the repression of deleterious accumulation of the RNA-DNA hybrid-harbouring R-loop structures. We also highlight the broader physiological roles of Ataxin-2 such as in the regulation of cellular metabolism and circadian rhythms. Finally, we discuss insight from clinically focused studies to shed light on the impact of molecular and physiological roles of Ataxin-2 in various human diseases. We anticipate that deciphering the fundamental functions of Ataxin-2 will uncover unique approaches to help cure or control debilitating and lethal human diseases. äAtaxin-2: From RNA Control to Human Health and Disease (epmc).pdf DeepDyve Pubget Overpricing