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10.3390/genes8060151 http://scihub22266oqcxt.onion/10.3390/genes8060151 C5485515!5485515!28587062     free     free     free       Genes+(Basel) 2017 ; 8 (6): ä Nephropedia Template TP {{tp|p=28587062|t=2017. MYC Deregulation in Primary Human Cancers |pdf=|usr=}}{{28587062}} gab.com Text MYC Deregulation in Primary Human Cancers JO: Genes (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=28587062 #FOAvip MYC regulates a complex biological program by transcriptionally activating and repressing its numerous target genes. As such, MYC is a master regulator of many processes, including cell cycle entry, ribosome biogenesis, and metabolism. In cancer, the activity of the MYC transcriptional network is frequently deregulated, contributing to the initiation and maintenance of disease. Deregulation often leads to constitutive overexpression of MYC, which can be achieved through gross genetic abnormalities, including copy number alterations, chromosomal translocations, increased enhancer activity, or through aberrant signal transduction leading to increased MYC transcription or increased MYC mRNA and protein stability. Herein, we summarize the frequency and modes of MYC deregulation and describe both well-established and more recent findings in a variety of cancer types. Notably, these studies have highlighted that with an increased appreciation for the basic mechanisms deregulating MYC in cancer, new therapeutic vulnerabilities can be discovered and potentially exploited for the inhibition of this potent oncogene in cancer. Twit Text FOAVip MYC Deregulation in Primary Human Cancers ????Genes (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=28587062 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28587062 #FOAvip English Wikipedia <ref>{{Cite pmid|28587062}}</ref> MYC Deregulation in Primary Human Cancers #MMPMID28587062 Kalkat M; De Melo J; Hickman KA; Lourenco C; Redel C; Resetca D; Tamachi A; Tu WB; Penn LZ Genes (Basel) 2017[Jun]; 8 (6): ä PMID28587062show ga MYC regulates a complex biological program by transcriptionally activating and repressing its numerous target genes. As such, MYC is a master regulator of many processes, including cell cycle entry, ribosome biogenesis, and metabolism. In cancer, the activity of the MYC transcriptional network is frequently deregulated, contributing to the initiation and maintenance of disease. Deregulation often leads to constitutive overexpression of MYC, which can be achieved through gross genetic abnormalities, including copy number alterations, chromosomal translocations, increased enhancer activity, or through aberrant signal transduction leading to increased MYC transcription or increased MYC mRNA and protein stability. Herein, we summarize the frequency and modes of MYC deregulation and describe both well-established and more recent findings in a variety of cancer types. Notably, these studies have highlighted that with an increased appreciation for the basic mechanisms deregulating MYC in cancer, new therapeutic vulnerabilities can be discovered and potentially exploited for the inhibition of this potent oncogene in cancer. äMYC Deregulation in Primary Human Cancers (epmc).pdf DeepDyve Pubget Overpricing