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10.3390/genes8060148

http://scihub22266oqcxt.onion/10.3390/genes8060148
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C5485512!5485512!28545252
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suck abstract from ncbi


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pmid28545252      Genes+(Basel) 2017 ; 8 (6): ä
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  • CpG and Non-CpG Methylation in Epigenetic Gene Regulation and Brain Function #MMPMID28545252
  • Jang HS; Shin WJ; Lee JE; Do JT
  • Genes (Basel) 2017[Jun]; 8 (6): ä PMID28545252show ga
  • DNA methylation is a major epigenetic mark with important roles in genetic regulation. Methylated cytosines are found primarily at CpG dinucleotides, but are also found at non-CpG sites (CpA, CpT, and CpC). The general functions of CpG and non-CpG methylation include gene silencing or activation depending on the methylated regions. CpG and non-CpG methylation are found throughout the whole genome, including repetitive sequences, enhancers, promoters, and gene bodies. Interestingly, however, non-CpG methylation is restricted to specific cell types, such as pluripotent stem cells, oocytes, neurons, and glial cells. Thus, accumulation of methylation at non-CpG sites and CpG sites in neurons seems to be involved in development and disease etiology. Here, we provide an overview of CpG and non-CpG methylation and their roles in neurological diseases.
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