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10.1038/onc.2016.485 http://scihub22266oqcxt.onion/10.1038/onc.2016.485 C5485177!5485177!28092669     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncogene 2017 ; 36 (24): 3359-74 Nephropedia Template TP {{tp|p=28092669|t=2017. Interplay between epigenetics and metabolism in oncogenesis: mechanisms and therapeutic approaches |pdf=|usr=}}{{28092669}} gab.com Text Interplay between epigenetics and metabolism in oncogenesis: mechanisms and therapeutic approaches JO: Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=28092669 #FOAvip Epigenetic and metabolic alterations in cancer cells are highly intertwined. Oncogene-driven metabolic rewiring modifies the epigenetic landscape via modulating the activities of DNA and histone modification enzymes at the metabolite level. Conversely, epigenetic mechanisms regulate the expression of metabolic genes, thereby altering the metabolome. Epigenetic-metabolomic interplay has a critical role in tumourigenesis by coordinately sustaining cell proliferation, metastasis and pluripotency. Understanding the link between epigenetics and metabolism could unravel novel molecular targets, whose intervention may lead to improvements in cancer treatment. In this review, we summarized the recent discoveries linking epigenetics and metabolism and their underlying roles in tumorigenesis; and highlighted the promising molecular targets, with an update on the development of small molecule or biologic inhibitors against these abnormalities in cancer. Twit Text FOAVip Interplay between epigenetics and metabolism in oncogenesis: mechanisms and therapeutic approaches ????Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=28092669 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28092669 #FOAvip English Wikipedia <ref>{{Cite pmid|28092669}}</ref> Interplay between epigenetics and metabolism in oncogenesis: mechanisms and therapeutic approaches #MMPMID28092669 Wong CC; Qian Y; Yu J Oncogene 2017[Jun]; 36 (24): 3359-74 PMID28092669show ga Epigenetic and metabolic alterations in cancer cells are highly intertwined. Oncogene-driven metabolic rewiring modifies the epigenetic landscape via modulating the activities of DNA and histone modification enzymes at the metabolite level. Conversely, epigenetic mechanisms regulate the expression of metabolic genes, thereby altering the metabolome. Epigenetic-metabolomic interplay has a critical role in tumourigenesis by coordinately sustaining cell proliferation, metastasis and pluripotency. Understanding the link between epigenetics and metabolism could unravel novel molecular targets, whose intervention may lead to improvements in cancer treatment. In this review, we summarized the recent discoveries linking epigenetics and metabolism and their underlying roles in tumorigenesis; and highlighted the promising molecular targets, with an update on the development of small molecule or biologic inhibitors against these abnormalities in cancer. äInterplay between epigenetics and metabolism in oncogenesis: mechanism(epmc).pdf DeepDyve Pubget Overpricing