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10.1002/jcp.25751 http://scihub22266oqcxt.onion/10.1002/jcp.25751 C5485033!5485033 !27996096     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27996096 &cmd=llinks): Failed to open stream: HTTP request failed! 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Super-resolution structure of DNA significantly differs in buccal cells of controls and Alzheimer s patients |pdf=|usr=}}{{27996096 }} gab.com Text Super-resolution structure of DNA significantly differs in buccal cells of controls and Alzheimer s patients JO: J Cell Physiol http://www.kidney.de/pget.php?&tw=1&pmid=27996096 #FOAvip The advent of super-resolution microscopy allowed for new insights into cellular and physiological processes of normal and diseased cells. In this study, we report for the first time on the super-resolved DNA structure of buccal cells from patients with Alzheimer's disease (AD) versus age- and gender-matched healthy, non-caregiver controls. In this super-resolution study cohort of 74 participants, buccal cells were collected and their spatial DNA organization in the nucleus examined by 3D Structured Illumination Microscopy (3D-SIM). Quantitation of the super-resolution DNA structure revealed that the nuclear super-resolution DNA structure of individuals with AD significantly differs from that of their controls (p?<?0.05) with an overall increase in the measured DNA-free/poor spaces. This represents a significant increase in the interchromatin compartment. We also find that the DNA structure of AD significantly differs in mild, moderate, and severe disease with respect to the DNA-containing and DNA-free/poor spaces. We conclude that whole genome remodeling is a feature of buccal cells in AD. Twit Text FOAVip Super-resolution structure of DNA significantly differs in buccal cells of controls and Alzheimer s patients ????J Cell Physiol http://www.kidney.de/pget.php?&tw=1&pmid=27996096 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27996096 #FOAvip English Wikipedia <ref>{{Cite pmid|27996096 }}</ref> Super-resolution structure of DNA significantly differs in buccal cells of controls and Alzheimer s patients #MMPMID27996096 Garcia A ; Huang D ; Righolt A ; Righolt C ; Kalaw MC ; Mathur S ; McAvoy E ; Anderson J ; Luedke A ; Itorralba J ; Mai S J Cell Physiol 2017[Sep]; 232 (9 ): 2387-2395 PMID27996096 show ga The advent of super-resolution microscopy allowed for new insights into cellular and physiological processes of normal and diseased cells. In this study, we report for the first time on the super-resolved DNA structure of buccal cells from patients with Alzheimer's disease (AD) versus age- and gender-matched healthy, non-caregiver controls. In this super-resolution study cohort of 74 participants, buccal cells were collected and their spatial DNA organization in the nucleus examined by 3D Structured Illumination Microscopy (3D-SIM). Quantitation of the super-resolution DNA structure revealed that the nuclear super-resolution DNA structure of individuals with AD significantly differs from that of their controls (p? |Aged [MESH] |Aged, 80 and over [MESH] |Alzheimer Disease/*genetics/*pathology [MESH] |Case-Control Studies [MESH] |Cell Nucleus/chemistry/*ultrastructure [MESH] |Chromatin Assembly and Disassembly [MESH] |Chromatin/*genetics/isolation & purification/*ultrastructure [MESH] |DNA/*genetics/isolation & purification/*ultrastructure [MESH] |Female [MESH] |Humans [MESH] |Imaging, Three-Dimensional [MESH] |Male [MESH] |Microscopy/methods [MESH] |Middle Aged [MESH] |Mouth Mucosa/chemistry/*ultrastructure [MESH] |Nucleic Acid Conformation [MESH]Super-resolution structure of DNA significantly differs in buccal cell(epmc).pdf DeepDyve Pubget Overpricing