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10.1126/science.aaf2807 http://scihub22266oqcxt.onion/10.1126/science.aaf2807 C5484795!5484795!27789795     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2016 ; 354 (6316): 1160-5 Nephropedia Template TP {{tp|p=27789795|t=2016. Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade |pdf=|usr=}}{{27789795}} gab.com Text Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=27789795 #FOAvip Blocking Programmed Death?1 (PD-1) can reinvigorate exhausted CD8 Tcells (TEX) and improve control of chronic infections and cancer. However, whether blocking PD-1 can reprogram TEX into durable memory Tcells (TMEM) is unclear. We found that reinvigoration of TEX in mice by PD-L1 blockade caused minimal memory development. After blockade, reinvigorated TEX became reexhausted if antigen concentration remained high and failed to become TMEM upon antigen clearance. TEX acquired an epigenetic profile distinct from that of effector Tcells (TEFF) and TMEM cells that was minimally remodeled after PD-L1 blockade. This finding suggests that TEX are a distinct lineage of CD8 Tcells. Nevertheless, PD-1 pathway blockade resulted in transcriptional rewiring and reengagement of effector circuitry in the TEX epigenetic landscape. These data indicate that epigenetic fate inflexibility may limit current immunotherapies. Twit Text FOAVip Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade ????Science http://www.kidney.de/pget.php?&tw=1&pmid=27789795 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27789795 #FOAvip English Wikipedia <ref>{{Cite pmid|27789795}}</ref> Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade #MMPMID27789795 Pauken KE; Sammons MA; Odorizzi PM; Manne S; Godec J; Khan O; Drake AM; Chen Z; Sen DR; Kurachi M; Barnitz RA; Bartman C; Bengsch B; Huang AC; Schenkel JM; Vahedi G; Haining WN; Berger SL; Wherry EJ Science 2016[Dec]; 354 (6316): 1160-5 PMID27789795show ga Blocking Programmed Death?1 (PD-1) can reinvigorate exhausted CD8 Tcells (TEX) and improve control of chronic infections and cancer. However, whether blocking PD-1 can reprogram TEX into durable memory Tcells (TMEM) is unclear. We found that reinvigoration of TEX in mice by PD-L1 blockade caused minimal memory development. After blockade, reinvigorated TEX became reexhausted if antigen concentration remained high and failed to become TMEM upon antigen clearance. TEX acquired an epigenetic profile distinct from that of effector Tcells (TEFF) and TMEM cells that was minimally remodeled after PD-L1 blockade. This finding suggests that TEX are a distinct lineage of CD8 Tcells. Nevertheless, PD-1 pathway blockade resulted in transcriptional rewiring and reengagement of effector circuitry in the TEX epigenetic landscape. These data indicate that epigenetic fate inflexibility may limit current immunotherapies. äEpigenetic stability of exhausted T cells limits durability of reinvig(epmc).pdf DeepDyve Pubget Overpricing