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10.1371/journal.pone.0180211 http://scihub22266oqcxt.onion/10.1371/journal.pone.0180211 C5484506!5484506 !28651015     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28651015 &cmd=llinks): Failed to open stream: HTTP request failed! 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Acute rejection after kidney transplantation promotes graft fibrosis with elevated adenosine level in rat |pdf=|usr=}}{{28651015 }} gab.com Text Acute rejection after kidney transplantation promotes graft fibrosis with elevated adenosine level in rat JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28651015 #FOAvip AIMS: Chronic allograft nephropathy is a worldwide issue with the major feature of progressive allograft fibrosis, eventually ending with graft loss. Adenosine has been demonstrated to play an important role in process of fibrosis. Our study aimed to investigate the relationship between adenosine and fibrosis in renal allograft acute rejection in rat. MATERIALS AND METHODS: Wistar rats and SD rats were selected as experimental animals. Our study designed two groups. In the allograft transplantation group, kidneys of Wistar rats were orthotopically transplanted into SD rat recipients, the same species but not genetically identical, to induce acute rejection. Kidney transplantations of SD rats to SD rats which were genetically identical were served as the control. We established rat models and detected a series of indicators. All data were analyzed statistically. P<0.05 was considered statistically significant. RESULTS: Compared with the control group, levels of adenosine increased significantly in the allograft transplantation group, in which acute rejection was induced (P<0.05). Progressive allograft fibrosis as well as collagen deposition were observed. CONCLUSIONS: These findings suggested that level of adenosine was upregulated in acute rejection after kidney allograft transplantation in rat. Acute rejection may promote renal allograft fibrosis via the adenosine signaling pathways. Twit Text FOAVip Acute rejection after kidney transplantation promotes graft fibrosis with elevated adenosine level in rat ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28651015 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28651015 #FOAvip English Wikipedia <ref>{{Cite pmid|28651015 }}</ref> Acute rejection after kidney transplantation promotes graft fibrosis with elevated adenosine level in rat #MMPMID28651015 Li M ; Dai Y ; Lei J ; Tang J ; Zhou Y ; Xia B ; Xia Y ; Yin G PLoS One 2017[]; 12 (6 ): e0180211 PMID28651015 show ga AIMS: Chronic allograft nephropathy is a worldwide issue with the major feature of progressive allograft fibrosis, eventually ending with graft loss. Adenosine has been demonstrated to play an important role in process of fibrosis. Our study aimed to investigate the relationship between adenosine and fibrosis in renal allograft acute rejection in rat. MATERIALS AND METHODS: Wistar rats and SD rats were selected as experimental animals. Our study designed two groups. In the allograft transplantation group, kidneys of Wistar rats were orthotopically transplanted into SD rat recipients, the same species but not genetically identical, to induce acute rejection. Kidney transplantations of SD rats to SD rats which were genetically identical were served as the control. We established rat models and detected a series of indicators. All data were analyzed statistically. P<0.05 was considered statistically significant. RESULTS: Compared with the control group, levels of adenosine increased significantly in the allograft transplantation group, in which acute rejection was induced (P<0.05). Progressive allograft fibrosis as well as collagen deposition were observed. CONCLUSIONS: These findings suggested that level of adenosine was upregulated in acute rejection after kidney allograft transplantation in rat. Acute rejection may promote renal allograft fibrosis via the adenosine signaling pathways. |Acute Disease [MESH] |Adenosine/*metabolism [MESH] |Allografts [MESH] |Animals [MESH] |Collagen/metabolism [MESH] |Fibrosis [MESH] |Graft Rejection/etiology/*metabolism/*pathology [MESH] |Isografts [MESH] |Kidney Transplantation/*adverse effects [MESH] |Kidney/metabolism/pathology [MESH] |Rats [MESH] |Rats, Sprague-Dawley [MESH]Acute rejection after kidney transplantation promotes graft fibrosis w(epmc).pdf DeepDyve Pubget Overpricing