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10.1038/nrg3956 http://scihub22266oqcxt.onion/10.1038/nrg3956 C5484418!5484418!26260262     free     free     free       Nat+Rev+Genet 2015 ; 16 (9): 501-16 Nephropedia Template TP {{tp|p=26260262|t=2015. Genomes by design |pdf=|usr=}}{{26260262}} gab.com Text Genomes by design JO: Nat Rev Genet http://www.kidney.de/pget.php?&tw=1&pmid=26260262 #FOAvip Next-generation DNA sequencing has revealed the complete genome sequences of numerous organisms, establishing a fundamental and growing understanding of genetic variation and phenotypic diversity. Engineering at the gene, network and whole-genome scale aims to introduce targeted genetic changes both to explore emergent phenotypes and to introduce new functionalities. Expansion of these approaches into massively parallel platforms establishes the ability to generate targeted genome modifications, elucidating causal links between genotype and phenotype, as well as the ability to design and reprogramme organisms. In this Review, we explore techniques and applications in genome engineering, outlining key advances and defining challenges. Twit Text FOAVip Genomes by design ????Nat Rev Genet http://www.kidney.de/pget.php?&tw=1&pmid=26260262 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26260262 #FOAvip English Wikipedia <ref>{{Cite pmid|26260262}}</ref> Genomes by design #MMPMID26260262 Haimovich AD; Muir P; Isaacs FJ Nat Rev Genet 2015[Sep]; 16 (9): 501-16 PMID26260262show ga Next-generation DNA sequencing has revealed the complete genome sequences of numerous organisms, establishing a fundamental and growing understanding of genetic variation and phenotypic diversity. Engineering at the gene, network and whole-genome scale aims to introduce targeted genetic changes both to explore emergent phenotypes and to introduce new functionalities. Expansion of these approaches into massively parallel platforms establishes the ability to generate targeted genome modifications, elucidating causal links between genotype and phenotype, as well as the ability to design and reprogramme organisms. In this Review, we explore techniques and applications in genome engineering, outlining key advances and defining challenges. äGenomes by design (epmc).pdf DeepDyve Pubget Overpricing