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10.1038/nrc.2016.71

http://scihub22266oqcxt.onion/10.1038/nrc.2016.71
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C5484415!5484415!27492215
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suck abstract from ncbi


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pmid27492215      Nat+Rev+Cancer 2016 ; 16 (10): 619-34
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  • From Krebs to Clinic: Glutamine Metabolism to Cancer Therapy #MMPMID27492215
  • Altman BJ; Stine ZE; Dang CV
  • Nat Rev Cancer 2016[Oct]; 16 (10): 619-34 PMID27492215show ga
  • The resurgence of research in cancer metabolism has recently broadened interests beyond glucose and the Warburg Effect to other nutrients including glutamine. Because oncogenic alterations of metabolism render cancer cells addicted to nutrients, pathways involved in glycolysis or glutaminolysis could be exploited for therapeutic purposes. In this Review, we provide an updated overview of glutamine metabolism and its involvement in tumorigenesis in vitro and in vivo, and explore the recent potential applications of basic science discoveries in the clinical setting.
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