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10.1111/dom.12878

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C5484336!5484336 !28094466
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suck abstract from ncbi


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pmid28094466
      Diabetes+Obes+Metab 2017 ; 19 (6 ): 800-808
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  • Effects of ?-blockers on all-cause mortality in patients with type 2 diabetes and coronary heart disease #MMPMID28094466
  • Tsujimoto T ; Sugiyama T ; Kajio H
  • Diabetes Obes Metab 2017[Jun]; 19 (6 ): 800-808 PMID28094466 show ga
  • AIMS: To assess whether the use of beta-blockers influences mortality and the incidence of major cardiovascular events in patients with diabetes and coronary heart disease (CHD). MATERIALS AND METHODS: Using data from the Bypass Angioplasty Revascularization Investigation 2 Diabetes trial, we performed Cox proportional hazards analysis to assess the effects of ?-blockers on all-cause mortality in 2244 patients with type 2 diabetes who had stable CHD with and without a history of myocardial infarction (MI)/heart failure with reduced left ventricular ejection fraction (HFrEF). RESULTS: All-cause mortality in patients with MI/HFrEF was significantly lower in those receiving ?-blockers than in those not receiving ?-blockers (adjusted hazard ratio [HR] 0.60, 95% confidence interval [CI] 0.37-0.98; P ?=?.04), whereas that in patients without MI/HFrEF did not significantly differ (adjusted HR 0.91, 95% CI 0.76-1.32; P ?=?.64). Among patients with MI/HFrEF, all-cause mortality in those who received intensive medical therapy alone for CHD was significantly lower in those on ?-blockers than in those not on ?-blockers (adjusted HR 0.45, 95% CI 0.23-0.88; P ?=?.02); however, mortality in patients who received early revascularization for CHD was not significantly lower in those on ?-blockers (adjusted HR 0.81, 95% CI 0.40-1.65; P ?=?.57). The risk of major cardiovascular events in patients without MI/HFrEF was not significantly different between those on and those not on ?-blocker treatment. CONCLUSIONS: In patients with diabetes and CHD, the use of ?-blockers was effective in reducing all-cause mortality in those with MI/HFrEF but not in those without MI/HFrEF.
  • |Adrenergic beta-Antagonists/*therapeutic use [MESH]
  • |Aged [MESH]
  • |Cause of Death [MESH]
  • |Coronary Disease/drug therapy/etiology/*mortality [MESH]
  • |Diabetes Mellitus, Type 2/complications/*mortality [MESH]
  • |Female [MESH]
  • |Heart Failure/drug therapy/etiology/mortality [MESH]
  • |Humans [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Myocardial Infarction/drug therapy/etiology/mortality [MESH]
  • |Proportional Hazards Models [MESH]
  • |Stroke Volume/drug effects [MESH]
  • |Treatment Outcome [MESH]


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