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2017 ; 41
(6
): 573-579
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Detection of Thrombosis in the Extracorporeal Membrane Oxygenation Circuit by
Infrasound: Proof of Concept
#MMPMID27654663
Fuchs G
; Berg N
; Eriksson A
; Prahl Wittberg L
Artif Organs
2017[Jun]; 41
(6
): 573-579
PMID27654663
show ga
As of today, there exist no reliable, objective methods for early detection of
thrombi in the extracorporeal membrane oxygenators (ECMO) system. Within the ECMO
system, thrombi are not always fixed to a certain component or location in the
circuit. Thus, clot fragments of different shapes and consistencies may circulate
and give rise to vibrations and sound generation. By bedside sound measurements
and additional laboratory experiments (although not detailed herein), we found
that the presence of particles (clots or aggregates and fragments of clots) can
be detected by analyzing the strength of infra-sound (< 20 Hz) modes of the
spectrum near the inlet and outlet of the centrifugal pump in the ECMO circuit.
For the few patients that were considered in this study, no clear false positive
or negative examples were found when comparing the spectral approach with
clinical observations. A laboratory setup provided insight to the flow in and out
of the pump, confirming that in the presence of particles a low-amplitude
low-frequency signal is strongly amplified, enabling the identification of a
clot.