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2017 ; 11
(5
): EC25-EC30
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Clinicopathological Analysis of Glomerular Disease of Adult Onset Nephrotic
Syndrome in an Indian Cohort- A Retrospective Study
#MMPMID28658768
Suryawanshi M
; Karnik S
; Roy S
J Clin Diagn Res
2017[May]; 11
(5
): EC25-EC30
PMID28658768
show ga
INTRODUCTION: Primary glomerular disease presenting with adult onset nephrotic
syndrome are a major cause of chronic renal failure worldwide. The spectrum of
renal disease presenting with nephrotic syndrome has undergone a gradual change
globally over the course of time. However, there still exist regional differences
in the incidence of primary glomerular diseases causing adult onset nephrotic
syndrome. AIM: To observe the spectrum of renal diseases presenting with adult
onset nephrotic syndrome with comparative analysis of changing trends over the
last five decades with regards to Western and Indian literature. MATERIALS AND
METHODS: Subjects included patients with age of 18-80 years presenting with
nephrotic syndrome. Renal biopsies with immunofluoroscence studies were performed
in all patients. Baseline clinical parameters of serum urea, creatinine, albumin,
globulin, cholesterol, 24 hour urine protein and urine microscopy were recorded.
Descriptive statistics was used and results were expressed as frequencies,
percentages, and meanąstandard deviation. RESULTS: A total of 227 patients (72%
males) were included for the study. Primary glomerular diseases formed 74.01% of
total cases and majority of patients included males in the 4(th) decade. Minimal
Change Disease (MCD) (15.8%) including its variants was the most common primary
glomerular disease for adult onset of nephrotic syndrome followed by Mesangial
proliferative Glomerulonephritis (MSGN) (13.2%). Membranous nephropathy and Type
I Membranoproliferative Glomerulonephritis (MPGN) individually accounted for
12.3% of patients. Focal and Segmental Glomerulosclerosis (FSGS) accounted for
only 11% of patients. Although, increased incidence of FSGS has been observed
worldwide, there exist important regional differences in primary glomerular
diseases in Indian population. MCD remains a major glomerular disease for adult
onset nephrotic syndrome in different parts of India. CONCLUSION: Our study over
three years represents important data of regional variations of primary
glomerular diseases presenting with adult onset nephrotic syndrome.