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10.1098/rstb.2016.0221 http://scihub22266oqcxt.onion/10.1098/rstb.2016.0221 C5483522!5483522!28630159     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Philos+Trans+R+Soc+Lond+B+Biol+Sci 2017 ; 372 (1726): ä Nephropedia Template TP {{tp|p=28630159|t=2017. The mystery behind membrane insertion: a review of the complement membrane attack complex |pdf=|usr=}}{{28630159}} gab.com Text The mystery behind membrane insertion: a review of the complement membrane attack complex JO: Philos Trans R Soc Lond B Biol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28630159 #FOAvip The membrane attack complex (MAC) is an important innate immune effector of the complement terminal pathway that forms cytotoxic pores on the surface of microbes. Despite many years of research, MAC structure and mechanism of action have remained elusive, relying heavily on modelling and inference from biochemical experiments. Recent advances in structural biology, specifically cryo-electron microscopy, have provided new insights into the molecular mechanism of MAC assembly. Its unique ?split-washer? shape, coupled with an irregular giant ?-barrel architecture, enable an atypical mechanism of hole punching and represent a novel system for which to study pore formation. This review will introduce the complement terminal pathway that leads to formation of the MAC. Moreover, it will discuss how structures of the pore and component proteins underpin a mechanism for MAC function, modulation and inhibition.This article is part of the themed issue ?Membrane pores: from structure and assembly, to medicine and technology?. Twit Text FOAVip The mystery behind membrane insertion: a review of the complement membrane attack complex ????Philos Trans R Soc Lond B Biol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28630159 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28630159 #FOAvip English Wikipedia <ref>{{Cite pmid|28630159}}</ref> The mystery behind membrane insertion: a review of the complement membrane attack complex #MMPMID28630159 Bayly-Jones C; Bubeck D; Dunstone MA Philos Trans R Soc Lond B Biol Sci 2017[Aug]; 372 (1726): ä PMID28630159show ga The membrane attack complex (MAC) is an important innate immune effector of the complement terminal pathway that forms cytotoxic pores on the surface of microbes. Despite many years of research, MAC structure and mechanism of action have remained elusive, relying heavily on modelling and inference from biochemical experiments. Recent advances in structural biology, specifically cryo-electron microscopy, have provided new insights into the molecular mechanism of MAC assembly. Its unique ?split-washer? shape, coupled with an irregular giant ?-barrel architecture, enable an atypical mechanism of hole punching and represent a novel system for which to study pore formation. This review will introduce the complement terminal pathway that leads to formation of the MAC. Moreover, it will discuss how structures of the pore and component proteins underpin a mechanism for MAC function, modulation and inhibition.This article is part of the themed issue ?Membrane pores: from structure and assembly, to medicine and technology?. äThe mystery behind membrane insertion: a review of the complement memb(epmc).pdf DeepDyve Pubget Overpricing