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10.1038/s41598-017-04045-5 http://scihub22266oqcxt.onion/10.1038/s41598-017-04045-5 C5482898!5482898 !28646235     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28646235 &cmd=llinks): Failed to open stream: HTTP request failed! 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Over Expression of Long Non-Coding RNA PANDA Promotes Hepatocellular Carcinoma by Inhibiting Senescence Associated Inflammatory Factor IL8 |pdf=|usr=}}{{28646235 }} gab.com Text Over Expression of Long Non-Coding RNA PANDA Promotes Hepatocellular Carcinoma by Inhibiting Senescence Associated Inflammatory Factor IL8 JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28646235 #FOAvip It has been reported that long non-coding RNA PANDA was disregulated in varieties types of tumor, but its expression level and biological role in hepatocellular carcinoma (HCC) remains contradictory. We detected PANDA expression in two independent cohorts (48 HCC patients following liver transplantation and 84 HCC patients following liver resection), and found that PANDA was down-regulated in HCC. Thereafter we explored its function in cancer biology by inversing its low expression. Surprisingly, overexpression of PANDA promoted HCC proliferation and carcinogenesis in vitro and in vivo. Mechanistically, PANDA repressed transcriptional activity of senescence associated inflammatory factor IL8, which leaded to inhibition of cellular senescence. Therefore, our research help to better understand the complex role of PANDA in HCC, and suggest more thoughtful strategies should be applied before it can be treated as a potential therapeutic target. Twit Text FOAVip Over Expression of Long Non-Coding RNA PANDA Promotes Hepatocellular Carcinoma by Inhibiting Senescence Associated Inflammatory Factor IL8 ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28646235 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28646235 #FOAvip English Wikipedia <ref>{{Cite pmid|28646235 }}</ref> Over Expression of Long Non-Coding RNA PANDA Promotes Hepatocellular Carcinoma by Inhibiting Senescence Associated Inflammatory Factor IL8 #MMPMID28646235 Peng C ; Hu W ; Weng X ; Tong R ; Cheng S ; Ding C ; Xiao H ; Lv Z ; Xie H ; Zhou L ; Wu J ; Zheng S Sci Rep 2017[Jun]; 7 (1 ): 4186 PMID28646235 show ga It has been reported that long non-coding RNA PANDA was disregulated in varieties types of tumor, but its expression level and biological role in hepatocellular carcinoma (HCC) remains contradictory. We detected PANDA expression in two independent cohorts (48 HCC patients following liver transplantation and 84 HCC patients following liver resection), and found that PANDA was down-regulated in HCC. Thereafter we explored its function in cancer biology by inversing its low expression. Surprisingly, overexpression of PANDA promoted HCC proliferation and carcinogenesis in vitro and in vivo. Mechanistically, PANDA repressed transcriptional activity of senescence associated inflammatory factor IL8, which leaded to inhibition of cellular senescence. Therefore, our research help to better understand the complex role of PANDA in HCC, and suggest more thoughtful strategies should be applied before it can be treated as a potential therapeutic target. |Animals [MESH] |Carcinogenesis/genetics/pathology [MESH] |Carcinoma, Hepatocellular/*genetics/*pathology [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation/genetics [MESH] |Cellular Senescence/*genetics [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Humans [MESH] |Inflammation/*pathology [MESH] |Interleukin-8/*metabolism [MESH] |Liver Neoplasms/*genetics/*pathology [MESH] |Mice [MESH] |Phenotype [MESH]Over Expression of Long Non-Coding RNA PANDA Promotes Hepatocellular C(epmc).pdf DeepDyve Pubget Overpricing