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10.1038/s41598-017-04438-6 http://scihub22266oqcxt.onion/10.1038/s41598-017-04438-6 C5482806!5482806!28646220     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28646220|t=2017. Angiotensin II synergizes with BAFF to promote atheroprotective regulatory B cells |pdf=|usr=}}{{28646220}} gab.com Text Angiotensin II synergizes with BAFF to promote atheroprotective regulatory B cells JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28646220 #FOAvip Angiotensin II (AngII) promotes hypertension, atherogenesis, vascular aneurysm and impairs post-ischemic cardiac remodeling through concerted roles on vascular cells, monocytes and T lymphocytes. However, the role of AngII in B lymphocyte responses is largely unexplored. Here, we show that chronic B cell depletion (Baffr deficiency) significantly reduces atherosclerosis in Apoe?/? mice infused with AngII. While adoptive transfer of B cells in Apoe?/?/Baffr?/? mice reversed atheroprotection in the absence of AngII, infusion of AngII in B cell replenished Apoe?/?/Baffr?/? mice unexpectedly prevented the progression of atherosclerosis. Atheroprotection observed in these mice was associated with a significant increase in regulatory CD1dhiCD5+ B cells, which produced high levels of interleukin (IL)-10 (B10 cells). Replenishment of Apoe?/?/Baffr?/? mice with Il10?/? B cells reversed AngII-induced B cell-dependent atheroprotection, thus highlighting a protective role of IL-10+ regulatory B cells in this setting. Transfer of AngII type 1A receptor deficient (Agtr1a?/?) B cells into Apoe?/?/Baffr?/? mice substantially reduced the production of IL-10 by B cells and prevented the AngII-dependent atheroprotective B cell phenotype. Consistent with the in vivo data, AngII synergized with BAFF to induce IL-10 production by B cells in vitro via AngII type 1A receptor. Our data demonstrate a previously unknown synergy between AngII and BAFF in inducing IL-10 production by B cells, resulting in atheroprotection. Twit Text FOAVip Angiotensin II synergizes with BAFF to promote atheroprotective regulatory B cells ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28646220 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28646220 #FOAvip English Wikipedia <ref>{{Cite pmid|28646220}}</ref> Angiotensin II synergizes with BAFF to promote atheroprotective regulatory B cells #MMPMID28646220 Ponnuswamy P; Joffre J; Herbin O; Esposito B; Laurans L; Binder CJ; Tedder TF; Zeboudj L; Loyer X; Giraud A; Zhang Y; Tedgui A; Mallat Z; Ait-Oufella H Sci Rep 2017[]; 7 (ä): ä PMID28646220show ga Angiotensin II (AngII) promotes hypertension, atherogenesis, vascular aneurysm and impairs post-ischemic cardiac remodeling through concerted roles on vascular cells, monocytes and T lymphocytes. However, the role of AngII in B lymphocyte responses is largely unexplored. Here, we show that chronic B cell depletion (Baffr deficiency) significantly reduces atherosclerosis in Apoe?/? mice infused with AngII. While adoptive transfer of B cells in Apoe?/?/Baffr?/? mice reversed atheroprotection in the absence of AngII, infusion of AngII in B cell replenished Apoe?/?/Baffr?/? mice unexpectedly prevented the progression of atherosclerosis. Atheroprotection observed in these mice was associated with a significant increase in regulatory CD1dhiCD5+ B cells, which produced high levels of interleukin (IL)-10 (B10 cells). Replenishment of Apoe?/?/Baffr?/? mice with Il10?/? B cells reversed AngII-induced B cell-dependent atheroprotection, thus highlighting a protective role of IL-10+ regulatory B cells in this setting. Transfer of AngII type 1A receptor deficient (Agtr1a?/?) B cells into Apoe?/?/Baffr?/? mice substantially reduced the production of IL-10 by B cells and prevented the AngII-dependent atheroprotective B cell phenotype. Consistent with the in vivo data, AngII synergized with BAFF to induce IL-10 production by B cells in vitro via AngII type 1A receptor. Our data demonstrate a previously unknown synergy between AngII and BAFF in inducing IL-10 production by B cells, resulting in atheroprotection. äAngiotensin II synergizes with BAFF to promote atheroprotective regula(epmc).pdf DeepDyve Pubget Overpricing