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10.1038/nrg.2016.11 http://scihub22266oqcxt.onion/10.1038/nrg.2016.11 C5482790!5482790!26972590     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Rev+Genet 2016 ; 17 (4): 239-50 Nephropedia Template TP {{tp|p=26972590|t=2016. Causes of molecular convergence and parallelism in protein evolution |pdf=|usr=}}{{26972590}} gab.com Text Causes of molecular convergence and parallelism in protein evolution JO: Nat Rev Genet http://www.kidney.de/pget.php?&tw=1&pmid=26972590 #FOAvip To what extent is the convergent evolution of protein function attributable to convergent or parallel changes at the amino acid level? The mutations that contribute to adaptive protein evolution may represent a biased subset of all possible beneficial mutations owing to mutation bias and/or variation in the magnitude of deleterious pleiotropy. A key finding is that the fitness effects of amino acid mutations are often conditional on genetic background. This context dependence (epistasis) can reduce the probability of convergence and parallelism because it reduces the number of possible mutations that are unconditionally acceptable in divergent genetic backgrounds. Here, I review factors that influence the probability of replicated evolution at the molecular level. Twit Text FOAVip Causes of molecular convergence and parallelism in protein evolution ????Nat Rev Genet http://www.kidney.de/pget.php?&tw=1&pmid=26972590 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26972590 #FOAvip English Wikipedia <ref>{{Cite pmid|26972590}}</ref> Causes of molecular convergence and parallelism in protein evolution #MMPMID26972590 Storz JF Nat Rev Genet 2016[Apr]; 17 (4): 239-50 PMID26972590show ga To what extent is the convergent evolution of protein function attributable to convergent or parallel changes at the amino acid level? The mutations that contribute to adaptive protein evolution may represent a biased subset of all possible beneficial mutations owing to mutation bias and/or variation in the magnitude of deleterious pleiotropy. A key finding is that the fitness effects of amino acid mutations are often conditional on genetic background. This context dependence (epistasis) can reduce the probability of convergence and parallelism because it reduces the number of possible mutations that are unconditionally acceptable in divergent genetic backgrounds. Here, I review factors that influence the probability of replicated evolution at the molecular level. äCauses of molecular convergence and parallelism in protein evolution (epmc).pdf DeepDyve Pubget Overpricing