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10.18632/oncotarget.15981 http://scihub22266oqcxt.onion/10.18632/oncotarget.15981 C5482702!5482702!28415662     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (22): 36832-44 Nephropedia Template TP {{tp|p=28415662|t=2017. The hypoxia signalling pathway in haematological malignancies |pdf=|usr=}}{{28415662}} gab.com Text The hypoxia signalling pathway in haematological malignancies JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28415662 #FOAvip Haematological malignancies are tumours that affect the haematopoietic and the lymphatic systems. Despite the huge efforts to eradicate these tumours, the percentage of patients suffering resistance to therapies and relapse still remains significant. The tumour environment favours drug resistance of cancer cells, and particularly of cancer stem/initiating cells. Hypoxia promotes aggressiveness, metastatic spread and relapse in most of the solid tumours. Furthermore, hypoxia is associated with worse prognosis and resistance to conventional treatments through activation of the hypoxia-inducible factors. Haematological malignancies are not considered solid tumours, and therefore, the role of hypoxia in these diseases was initially presumed to be inconsequential. However, hypoxia is a hallmark of the haematopoietic niche. Here, we will review the current understanding of the role of both hypoxia and hypoxia-inducible factors in different haematological tumours. Twit Text FOAVip The hypoxia signalling pathway in haematological malignancies ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28415662 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28415662 #FOAvip English Wikipedia <ref>{{Cite pmid|28415662}}</ref> The hypoxia signalling pathway in haematological malignancies #MMPMID28415662 Irigoyen M; García-Ruiz JC; Berra E Oncotarget 2017[May]; 8 (22): 36832-44 PMID28415662show ga Haematological malignancies are tumours that affect the haematopoietic and the lymphatic systems. Despite the huge efforts to eradicate these tumours, the percentage of patients suffering resistance to therapies and relapse still remains significant. The tumour environment favours drug resistance of cancer cells, and particularly of cancer stem/initiating cells. Hypoxia promotes aggressiveness, metastatic spread and relapse in most of the solid tumours. Furthermore, hypoxia is associated with worse prognosis and resistance to conventional treatments through activation of the hypoxia-inducible factors. Haematological malignancies are not considered solid tumours, and therefore, the role of hypoxia in these diseases was initially presumed to be inconsequential. However, hypoxia is a hallmark of the haematopoietic niche. Here, we will review the current understanding of the role of both hypoxia and hypoxia-inducible factors in different haematological tumours. äThe hypoxia signalling pathway in haematological malignancies (epmc).pdf DeepDyve Pubget Overpricing