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10.18632/oncotarget.16414 http://scihub22266oqcxt.onion/10.18632/oncotarget.16414 C5482630!5482630 !28415591     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28415591 &cmd=llinks): Failed to open stream: HTTP request failed! 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The purinergic receptor subtype P2Y2 mediates chemotaxis of neutrophils and fibroblasts in fibrotic lung disease |pdf=|usr=}}{{28415591 }} gab.com Text The purinergic receptor subtype P2Y2 mediates chemotaxis of neutrophils and fibroblasts in fibrotic lung disease JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28415591 #FOAvip Idiopathic pulmonary fibrosis (IPF) is a devastating disease with few available treatment options. Recently, the involvement of purinergic receptor subtypes in the pathogenesis of different lung diseases has been demonstrated. Here we investigated the role of the purinergic receptor subtype P2Y2 in the context of fibrotic lung diseases.The concentration of different nucleotides was measured in the broncho-alveolar lavage (BAL) fluid derived from IPF patients and animals with bleomycin-induced pulmonary fibrosis. In addition expression of P2Y2 receptors by different cell types was determined. To investigate the functional relevance of P2Y2 receptors for the pathogenesis of the disease the bleomycin model of pulmonary fibrosis was used. Finally, experiments were performed in pursuit of the involved mechanisms.Compared to healthy individuals or vehicle treated animals, extracellular nucleotide levels in the BAL fluid were increased in patients with IPF and in mice after bleomycin administration, paralleled by a functional up-regulation of P2Y2R expression. Both bleomycin-induced inflammation and fibrosis were reduced in P2Y2R-deficient compared to wild type animals. Mechanistic studies demonstrated that recruitment of neutrophils into the lungs, proliferation and migration of lung fibroblasts as well as IL6 production are key P2Y2R mediated processes.Our results clearly demonstrate the involvement of P2Y2R subtypes in the pathogenesis of fibrotic lung diseases in humans and mice and hence support the development of selective P2Y2R antagonists for the treatment of IPF. Twit Text FOAVip The purinergic receptor subtype P2Y2 mediates chemotaxis of neutrophils and fibroblasts in fibrotic lung disease ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28415591 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28415591 #FOAvip English Wikipedia <ref>{{Cite pmid|28415591 }}</ref> The purinergic receptor subtype P2Y2 mediates chemotaxis of neutrophils and fibroblasts in fibrotic lung disease #MMPMID28415591 Müller T ; Fay S ; Vieira RP ; Karmouty-Quintana H ; Cicko S ; Ayata K ; Zissel G ; Goldmann T ; Lungarella G ; Ferrari D ; Di Virgilio F ; Robaye B ; Boeynaems JM ; Blackburn MR ; Idzko M Oncotarget 2017[May]; 8 (22 ): 35962-35972 PMID28415591 show ga Idiopathic pulmonary fibrosis (IPF) is a devastating disease with few available treatment options. Recently, the involvement of purinergic receptor subtypes in the pathogenesis of different lung diseases has been demonstrated. Here we investigated the role of the purinergic receptor subtype P2Y2 in the context of fibrotic lung diseases.The concentration of different nucleotides was measured in the broncho-alveolar lavage (BAL) fluid derived from IPF patients and animals with bleomycin-induced pulmonary fibrosis. In addition expression of P2Y2 receptors by different cell types was determined. To investigate the functional relevance of P2Y2 receptors for the pathogenesis of the disease the bleomycin model of pulmonary fibrosis was used. Finally, experiments were performed in pursuit of the involved mechanisms.Compared to healthy individuals or vehicle treated animals, extracellular nucleotide levels in the BAL fluid were increased in patients with IPF and in mice after bleomycin administration, paralleled by a functional up-regulation of P2Y2R expression. Both bleomycin-induced inflammation and fibrosis were reduced in P2Y2R-deficient compared to wild type animals. Mechanistic studies demonstrated that recruitment of neutrophils into the lungs, proliferation and migration of lung fibroblasts as well as IL6 production are key P2Y2R mediated processes.Our results clearly demonstrate the involvement of P2Y2R subtypes in the pathogenesis of fibrotic lung diseases in humans and mice and hence support the development of selective P2Y2R antagonists for the treatment of IPF. |Adenosine Triphosphate/metabolism [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Animals [MESH] |Biomarkers [MESH] |Cell Proliferation [MESH] |Chemotaxis/*immunology [MESH] |Disease Models, Animal [MESH] |Extracellular Space/metabolism [MESH] |Female [MESH] |Fibroblasts/*metabolism [MESH] |Fibrosis [MESH] |Gene Expression [MESH] |Humans [MESH] |Idiopathic Pulmonary Fibrosis/*metabolism/*pathology/physiopathology [MESH] |Male [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Middle Aged [MESH] |Neutrophils/*immunology/*metabolism [MESH] |Receptors, Purinergic P2Y2/genetics/*metabolism [MESH]The purinergic receptor subtype P2Y2 mediates chemotaxis of neutrophil(epmc).pdf DeepDyve Pubget Overpricing