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10.18632/oncotarget.10572 http://scihub22266oqcxt.onion/10.18632/oncotarget.10572 C5482607!5482607!27447964     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (22): 35669-80 Nephropedia Template TP {{tp|p=27447964|t=2017. Ultraconserved long non-coding RNA uc 63 in breast cancer |pdf=|usr=}}{{27447964}} gab.com Text Ultraconserved long non-coding RNA uc 63 in breast cancer JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27447964 #FOAvip Transcribed-ultraconserved regions (T-UCRs) are long non-coding RNAs (lncRNA) encoded by a subset of long ultraconserved stretches in the human genome. Recent studies revealed that the expression of several T-UCRs is altered in cancer and growing evidences underline the importance of T-UCRs in oncogenesis, offering also potential new strategies for diagnosis and prognosis. We found that overexpression of one specific T-UCRs named uc.63 is associated with bad outcome in luminal A subtype of breast cancer patients. uc.63 is localized in the third intron of exportin-1 gene (XPO1) and is transcribed in the same orientation of its host gene. Interestingly, silencing of uc.63 induces apoptosis in vitro. However, silencing of host gene XPO1 does not cause the same effect suggesting that the transcription of uc.63 is independent of XPO1. Our results reveal an important role of uc.63 in promoting breast cancer cells survival and offer the prospect to identify a signature associated with poor prognosis. Twit Text FOAVip Ultraconserved long non-coding RNA uc 63 in breast cancer ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27447964 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27447964 #FOAvip English Wikipedia <ref>{{Cite pmid|27447964}}</ref> Ultraconserved long non-coding RNA uc 63 in breast cancer #MMPMID27447964 Marini A; Lena AM; Panatta E; Ivan C; Han L; Liang H; Annicchiarico-Petruzzelli M; Di Daniele N; Calin GA; Candi E; Melino G Oncotarget 2017[May]; 8 (22): 35669-80 PMID27447964show ga Transcribed-ultraconserved regions (T-UCRs) are long non-coding RNAs (lncRNA) encoded by a subset of long ultraconserved stretches in the human genome. Recent studies revealed that the expression of several T-UCRs is altered in cancer and growing evidences underline the importance of T-UCRs in oncogenesis, offering also potential new strategies for diagnosis and prognosis. We found that overexpression of one specific T-UCRs named uc.63 is associated with bad outcome in luminal A subtype of breast cancer patients. uc.63 is localized in the third intron of exportin-1 gene (XPO1) and is transcribed in the same orientation of its host gene. Interestingly, silencing of uc.63 induces apoptosis in vitro. However, silencing of host gene XPO1 does not cause the same effect suggesting that the transcription of uc.63 is independent of XPO1. Our results reveal an important role of uc.63 in promoting breast cancer cells survival and offer the prospect to identify a signature associated with poor prognosis. äUltraconserved long non-coding RNA uc 63 in breast cancer (epmc).pdf DeepDyve Pubget Overpricing