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10.18632/oncotarget.16022 http://scihub22266oqcxt.onion/10.18632/oncotarget.16022 C5482601!5482601 !28423685     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28423685 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2017 ; 8 (22 ): 35592-35608 Nephropedia Template TP {{tp|p=28423685 |t=2017. Tumor-fibroblast interactions stimulate tumor vascularization by enhancing cytokine-driven production of MMP9 by tumor cells |pdf=|usr=}}{{28423685 }} gab.com Text Tumor-fibroblast interactions stimulate tumor vascularization by enhancing cytokine-driven production of MMP9 by tumor cells JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28423685 #FOAvip Advance-stage breast carcinomas include significant amounts of fibroblasts and infiltrating immune cells which have been implicated in tumor growth, recurrence, and response to therapy. The present study investigated the contribution of fibroblasts to tumor growth using direct tumor-fibroblast co-cultures and tumor xenograft models. Our findings revealed that fibroblasts enhance breast carcinoma growth by promoting the tumor vasculature via the MMP9-dependent mechanism. In tumor-fibroblast co-cultures, fibroblasts increased expression of TGF-?, TNF, and IL-1? cytokines in tumor cells. These cytokines cooperatively induced expression of matrix metalloproteinase MMP9 in tumor cells. Knockdown of MMP9 by shRNA significantly reduced tumor vascularization induced by fibroblasts. Mechanistically, our findings argue that expression of MMP9 in tumor cellsis regulated by crosstalk of TGF-? with TNF and/or IL-1? cytokines. The mechanism of this cooperative response did not involve cross-activation of the canonical signaling pathways as TGF-? did not activate RELA/p65 signaling, while TNF did not affect SMAD signaling. Instead, TGF-? and TNF cytokines co-stimulated MAP kinases and expression of JUN and JUNB, AP1 transcription factor subunits, which together with RELA/p65 were essential for the regulation of MMP9. Depletion of JUN and JUNB or RELA in tumor cells blocked the cooperative induction of MMP9 by the cytokines. Thus, our studies uncovered a previously unappreciated role of tumor-fibroblast interactions in the stimulation of tumor angiogenesis, and an essential role of the MAPK-AP1 axis in the cooperative up-regulation of the angiogenic driver MMP9 by cytokine crosstalk. Twit Text FOAVip Tumor-fibroblast interactions stimulate tumor vascularization by enhancing cytokine-driven production of MMP9 by tumor cells ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28423685 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28423685 #FOAvip English Wikipedia <ref>{{Cite pmid|28423685 }}</ref> Tumor-fibroblast interactions stimulate tumor vascularization by enhancing cytokine-driven production of MMP9 by tumor cells #MMPMID28423685 Limoge M ; Safina A ; Beattie A ; Kapus L ; Truskinovsky AM ; Bakin AV Oncotarget 2017[May]; 8 (22 ): 35592-35608 PMID28423685 show ga Advance-stage breast carcinomas include significant amounts of fibroblasts and infiltrating immune cells which have been implicated in tumor growth, recurrence, and response to therapy. The present study investigated the contribution of fibroblasts to tumor growth using direct tumor-fibroblast co-cultures and tumor xenograft models. Our findings revealed that fibroblasts enhance breast carcinoma growth by promoting the tumor vasculature via the MMP9-dependent mechanism. In tumor-fibroblast co-cultures, fibroblasts increased expression of TGF-?, TNF, and IL-1? cytokines in tumor cells. These cytokines cooperatively induced expression of matrix metalloproteinase MMP9 in tumor cells. Knockdown of MMP9 by shRNA significantly reduced tumor vascularization induced by fibroblasts. Mechanistically, our findings argue that expression of MMP9 in tumor cellsis regulated by crosstalk of TGF-? with TNF and/or IL-1? cytokines. The mechanism of this cooperative response did not involve cross-activation of the canonical signaling pathways as TGF-? did not activate RELA/p65 signaling, while TNF did not affect SMAD signaling. Instead, TGF-? and TNF cytokines co-stimulated MAP kinases and expression of JUN and JUNB, AP1 transcription factor subunits, which together with RELA/p65 were essential for the regulation of MMP9. Depletion of JUN and JUNB or RELA in tumor cells blocked the cooperative induction of MMP9 by the cytokines. Thus, our studies uncovered a previously unappreciated role of tumor-fibroblast interactions in the stimulation of tumor angiogenesis, and an essential role of the MAPK-AP1 axis in the cooperative up-regulation of the angiogenic driver MMP9 by cytokine crosstalk. |Animals [MESH] |Apoptosis [MESH] |Cancer-Associated Fibroblasts/*metabolism [MESH] |Cell Communication [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation [MESH] |Cells, Cultured [MESH] |Coculture Techniques [MESH] |Cytokines/*metabolism [MESH] |Disease Models, Animal [MESH] |Female [MESH] |Humans [MESH] |Inflammation Mediators [MESH] |MAP Kinase Kinase Kinases/metabolism [MESH] |Matrix Metalloproteinase 9/*metabolism [MESH] |Mice [MESH] |Neoplasms/metabolism/pathology [MESH] |Neovascularization, Pathologic/*metabolism [MESH] |Rats [MESH] |Signal Transduction [MESH] |Transcription Factor RelA/metabolism [MESH] |Transforming Growth Factor beta/metabolism [MESH] |Tumor Necrosis Factor-alpha/metabolism [MESH]Tumor-fibroblast interactions stimulate tumor vascularization by enhan(epmc).pdf DeepDyve Pubget Overpricing