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10.1016/j.trecan.2017.04.008 http://scihub22266oqcxt.onion/10.1016/j.trecan.2017.04.008 C5482322!5482322!28670628     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Trends+Cancer 2017 ; 3 (6): 391-406 Nephropedia Template TP {{tp|p=28670628|t=2017. Migrastatics?Anti-metastatic and Anti-invasion Drugs: Promises and Challenges |pdf=|usr=}}{{28670628}} gab.com Text Migrastatics Anti-metastatic and Anti-invasion Drugs: Promises and Challenges JO: Trends Cancer http://www.kidney.de/pget.php?&tw=1&pmid=28670628 #FOAvip In solid cancers, invasion and metastasis account for more than 90% of mortality. However, in the current armory of anticancer therapies, a specific category of anti-invasion and antimetastatic drugs is missing. Here, we coin the term ?migrastatics? for drugs interfering with all modes of cancer cell invasion and metastasis, to distinguish this class from conventional cytostatic drugs, which are mainly directed against cell proliferation. We define actin polymerization and contractility as target mechanisms for migrastatics, and review candidate migrastatic drugs. Critical assessment of these antimetastatic agents is warranted, because they may define new options for the treatment of solid cancers. Twit Text FOAVip Migrastatics Anti-metastatic and Anti-invasion Drugs: Promises and Challenges ????Trends Cancer http://www.kidney.de/pget.php?&tw=1&pmid=28670628 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28670628 #FOAvip English Wikipedia <ref>{{Cite pmid|28670628}}</ref> Migrastatics?Anti-metastatic and Anti-invasion Drugs: Promises and Challenges #MMPMID28670628 Gandalovi?ová A; Rosel D; Fernandes M; Veselý P; Heneberg P; ?ermák V; Petru?elka L; Kumar S; Sanz-Moreno V; Brábek J Trends Cancer 2017[Jun]; 3 (6): 391-406 PMID28670628show ga In solid cancers, invasion and metastasis account for more than 90% of mortality. However, in the current armory of anticancer therapies, a specific category of anti-invasion and antimetastatic drugs is missing. Here, we coin the term ?migrastatics? for drugs interfering with all modes of cancer cell invasion and metastasis, to distinguish this class from conventional cytostatic drugs, which are mainly directed against cell proliferation. We define actin polymerization and contractility as target mechanisms for migrastatics, and review candidate migrastatic drugs. Critical assessment of these antimetastatic agents is warranted, because they may define new options for the treatment of solid cancers. äMigrastatics?Anti-metastatic and Anti-invasion Drugs: Promises and Cha(epmc).pdf DeepDyve Pubget Overpricing