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10.3892/mmr.2017.6628 http://scihub22266oqcxt.onion/10.3892/mmr.2017.6628 C5482200!5482200 !28560403     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28560403 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Med+Rep 2017 ; 16 (1 ): 737-745 Nephropedia Template TP {{tp|p=28560403 |t=2017. Anti?fibrotic effect of Sedum sarmentosum Bunge extract in kidneys via the hedgehog signaling pathway |pdf=|usr=}}{{28560403 }} gab.com Text Anti fibrotic effect of Sedum sarmentosum Bunge extract in kidneys via the hedgehog signaling pathway JO: Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=28560403 #FOAvip Sedum sarmentosum Bunge (SSBE) is a perennial plant widely distributed in Asian countries, and its extract is traditionally used for the treatment of certain inflammatory diseases. Our previous studies demonstrated that SSBE has marked renal anti?fibrotic effects. However, the underlying molecular mechanisms remain to be fully elucidated. The present study identified that SSBE exerts its inhibitory effect on the myofibroblast phenotype and renal fibrosis via the hedgehog signaling pathway in vivo and in vitro. In rats with unilateral ureteral obstruction (UUO), SSBE administration reduced kidney injury and alleviated interstitial fibrosis by decreasing the levels of transforming growth factor (TGF)??1 and its receptor, and inhibiting excessive accumulation of extracellular matrix (ECM) components, including type I and III collagens. In addition, SSBE suppressed the expression of proliferating cell nuclear antigen, and this anti?proliferative activity was associated with downregulation of hedgehog signaling activity in SSBE?treated UUO kidneys. In cultured renal tubular epithelial cells (RTECs), recombinant TGF??1 activated hedgehog signaling, and resulted in induction of the myofibroblast phenotype. SSBE treatment inhibited the activation of hedgehog signaling and partially reversed the fibrotic phenotype in TGF??1?treated RTECs. Similarly, aristolochic acid?mediated upregulated activity of hedgehog signaling was reduced by SSBE treatment, and thereby led to the abolishment of excessive ECM accumulation. Therefore, these findings suggested that SSBE attenuates the myofibroblast phenotype and renal fibrosis via suppressing the hedgehog signaling pathway, and may facilitate the development of treatments for kidney fibrosis. Twit Text FOAVip Anti fibrotic effect of Sedum sarmentosum Bunge extract in kidneys via the hedgehog signaling pathway ????Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=28560403 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28560403 #FOAvip English Wikipedia <ref>{{Cite pmid|28560403 }}</ref> Anti?fibrotic effect of Sedum sarmentosum Bunge extract in kidneys via the hedgehog signaling pathway #MMPMID28560403 Bai Y ; Wu C ; Hong W ; Zhang X ; Liu L ; Chen B Mol Med Rep 2017[Jul]; 16 (1 ): 737-745 PMID28560403 show ga Sedum sarmentosum Bunge (SSBE) is a perennial plant widely distributed in Asian countries, and its extract is traditionally used for the treatment of certain inflammatory diseases. Our previous studies demonstrated that SSBE has marked renal anti?fibrotic effects. However, the underlying molecular mechanisms remain to be fully elucidated. The present study identified that SSBE exerts its inhibitory effect on the myofibroblast phenotype and renal fibrosis via the hedgehog signaling pathway in vivo and in vitro. In rats with unilateral ureteral obstruction (UUO), SSBE administration reduced kidney injury and alleviated interstitial fibrosis by decreasing the levels of transforming growth factor (TGF)??1 and its receptor, and inhibiting excessive accumulation of extracellular matrix (ECM) components, including type I and III collagens. In addition, SSBE suppressed the expression of proliferating cell nuclear antigen, and this anti?proliferative activity was associated with downregulation of hedgehog signaling activity in SSBE?treated UUO kidneys. In cultured renal tubular epithelial cells (RTECs), recombinant TGF??1 activated hedgehog signaling, and resulted in induction of the myofibroblast phenotype. SSBE treatment inhibited the activation of hedgehog signaling and partially reversed the fibrotic phenotype in TGF??1?treated RTECs. Similarly, aristolochic acid?mediated upregulated activity of hedgehog signaling was reduced by SSBE treatment, and thereby led to the abolishment of excessive ECM accumulation. Therefore, these findings suggested that SSBE attenuates the myofibroblast phenotype and renal fibrosis via suppressing the hedgehog signaling pathway, and may facilitate the development of treatments for kidney fibrosis. |Animals [MESH] |Biomarkers [MESH] |Cell Line [MESH] |Epithelial Cells/drug effects/metabolism [MESH] |Epithelial-Mesenchymal Transition/drug effects [MESH] |Extracellular Matrix/metabolism [MESH] |Fibrosis [MESH] |Gene Expression Regulation [MESH] |Hedgehog Proteins/*metabolism [MESH] |Immunohistochemistry [MESH] |Kidney Diseases/drug therapy/genetics/metabolism/pathology [MESH] |Kidney/*metabolism/pathology [MESH] |Male [MESH] |Plant Extracts/*pharmacology [MESH] |Rats [MESH] |Sedum/*chemistry [MESH] |Signal Transduction/*drug effects [MESH]Anti?fibrotic effect of Sedum sarmentosum Bunge extract in kidneys via(epmc).pdf DeepDyve Pubget Overpricing