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10.3892/mmr.2017.6637 http://scihub22266oqcxt.onion/10.3892/mmr.2017.6637 C5482143!5482143 !28560428     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28560428 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Med+Rep 2017 ; 16 (1 ): 680-686 Nephropedia Template TP {{tp|p=28560428 |t=2017. Metformin ameliorates hepatic steatosis and improves the induction of autophagy in HFD?induced obese mice |pdf=|usr=}}{{28560428 }} gab.com Text Metformin ameliorates hepatic steatosis and improves the induction of autophagy in HFD induced obese mice JO: Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=28560428 #FOAvip The present study aimed to investigate the effect of metformin on the induction of autophagy in the liver and adipose tissues of a mouse model of obesity. C57BL/6J mice were fed a high?fat diet (HFD) for 12 weeks to induce obesity?associated hepatic steatosis, and treated with metformin (150 mg/kg/d) by intraperitoneal injection for the final 4 weeks of HFD feeding. Body weight was recorded weekly, and the food intake of the mice was recorded daily during the treatment period. Liver and adipose tissues were harvested for histological and molecular analyses. The results revealed that metformin significantly reduced body weight without altering food intake in the HFD mice, particularly in the epididymal white adipose tissue (eWAT). Metformin treatment ameliorated HFD?induced hepatic steatosis and serum levels of triglycerides, which was consistent with a marked increase in the expression levels of microtubule?associated protein 1 light chain 3 (LC3) and AMP?activated protein kinase (AMPK) in the liver following metformin treatment. However, metformin suppressed the expression of LC3 in the eWAT without altering the expression of AMPK, compared with that in the HFD mice. In conclusion, metformin reduced the body weight and hepatic steatosis of the HFD?induced obese mice, without altering food intake. The effects of metformin treatment may be attributable to the improved induction of hepatic autophagy and the inhibited induction of adipose tissue autophagy. Twit Text FOAVip Metformin ameliorates hepatic steatosis and improves the induction of autophagy in HFD induced obese mice ????Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=28560428 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28560428 #FOAvip English Wikipedia <ref>{{Cite pmid|28560428 }}</ref> Metformin ameliorates hepatic steatosis and improves the induction of autophagy in HFD?induced obese mice #MMPMID28560428 Li M ; Sharma A ; Yin C ; Tan X ; Xiao Y Mol Med Rep 2017[Jul]; 16 (1 ): 680-686 PMID28560428 show ga The present study aimed to investigate the effect of metformin on the induction of autophagy in the liver and adipose tissues of a mouse model of obesity. C57BL/6J mice were fed a high?fat diet (HFD) for 12 weeks to induce obesity?associated hepatic steatosis, and treated with metformin (150 mg/kg/d) by intraperitoneal injection for the final 4 weeks of HFD feeding. Body weight was recorded weekly, and the food intake of the mice was recorded daily during the treatment period. Liver and adipose tissues were harvested for histological and molecular analyses. The results revealed that metformin significantly reduced body weight without altering food intake in the HFD mice, particularly in the epididymal white adipose tissue (eWAT). Metformin treatment ameliorated HFD?induced hepatic steatosis and serum levels of triglycerides, which was consistent with a marked increase in the expression levels of microtubule?associated protein 1 light chain 3 (LC3) and AMP?activated protein kinase (AMPK) in the liver following metformin treatment. However, metformin suppressed the expression of LC3 in the eWAT without altering the expression of AMPK, compared with that in the HFD mice. In conclusion, metformin reduced the body weight and hepatic steatosis of the HFD?induced obese mice, without altering food intake. The effects of metformin treatment may be attributable to the improved induction of hepatic autophagy and the inhibited induction of adipose tissue autophagy. |*Diet, High-Fat [MESH] |AMP-Activated Protein Kinases/genetics/metabolism [MESH] |Adipose Tissue/metabolism [MESH] |Animals [MESH] |Autophagy/*drug effects [MESH] |Body Weight/drug effects [MESH] |Disease Models, Animal [MESH] |Fatty Liver/drug therapy/*etiology/*metabolism/pathology [MESH] |Gene Expression [MESH] |Immunohistochemistry [MESH] |Lipid Metabolism/drug effects [MESH] |Liver/anatomy & histology/drug effects/metabolism [MESH] |Male [MESH] |Metformin/*pharmacology [MESH] |Mice [MESH] |Microtubule-Associated Proteins/genetics/metabolism [MESH]Metformin ameliorates hepatic steatosis and improves the induction of (epmc).pdf DeepDyve Pubget Overpricing