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10.3892/mmr.2017.6562 http://scihub22266oqcxt.onion/10.3892/mmr.2017.6562 C5482119!5482119!28498479     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Med+Rep 2017 ; 16 (1): 49-56 Nephropedia Template TP {{tp|p=28498479|t=2017. PPAR-? improves the recovery of lung function following acute respiratory distress syndrome by suppressing the level of TGF-?1 |pdf=|usr=}}{{28498479}} gab.com Text PPAR- improves the recovery of lung function following acute respiratory distress syndrome by suppressing the level of TGF- 1 JO: Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=28498479 #FOAvip Although peroxisome proliferator-activated receptor (PPAR)-? has been reported to be involved in preventing acute lung injury (ALI), the molecular regulation of post-ALI lung recovery remains to be fully elucidated. The aim of the present study was to characterize the mechanism by which PPAR-? prevents ALI and examine the role of PPAR-? in the recovery of lung function following acute respiratory distress syndrome (ARDS). Reverse transcription-quantitative-polymerase chain reaction and western blot analyses suggested that PPAR-? was effective in suppressing transforming growth factor (TGF)-?1 in HLF cells and RAW 264.7 cells. In an ALI mouse model, PPAR-? treatment prior to stimulation with lipopolysaccharide (LPS) resulted in a decrease in the expression of TGF-?1 in bronchoalveolar lavage fluid (BALF), peripheral blood and splenocytes. The injection of a virus expressing short hairpin PPAR-? into mice following LPS treatment resulted in a dose-dependent increase in lung resistance index and decrease in dynamic compliance, and a significant increase in BALF protein, which indicated PPAR-? was essential for the recovery of lung function following ALI. Of note, the serum expression of PPAR-? was inversely correlated with TGF-?1 and negatively correlated with disease severity in patients with ARDS. These data suggested that PPAR-? was essential for the recovery of lung function following ALI by the suppression of TGF-?1, which reveals a previously unappreciated mechanism controlling post-ALI lung recovery. Twit Text FOAVip PPAR- improves the recovery of lung function following acute respiratory distress syndrome by suppressing the level of TGF- 1 ????Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=28498479 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28498479 #FOAvip English Wikipedia <ref>{{Cite pmid|28498479}}</ref> PPAR-? improves the recovery of lung function following acute respiratory distress syndrome by suppressing the level of TGF-?1 #MMPMID28498479 Liu Y; Xie L; Yang M; Tan X; Zeng Y; Zheng G; Chen Y; Chen P Mol Med Rep 2017[Jul]; 16 (1): 49-56 PMID28498479show ga Although peroxisome proliferator-activated receptor (PPAR)-? has been reported to be involved in preventing acute lung injury (ALI), the molecular regulation of post-ALI lung recovery remains to be fully elucidated. The aim of the present study was to characterize the mechanism by which PPAR-? prevents ALI and examine the role of PPAR-? in the recovery of lung function following acute respiratory distress syndrome (ARDS). Reverse transcription-quantitative-polymerase chain reaction and western blot analyses suggested that PPAR-? was effective in suppressing transforming growth factor (TGF)-?1 in HLF cells and RAW 264.7 cells. In an ALI mouse model, PPAR-? treatment prior to stimulation with lipopolysaccharide (LPS) resulted in a decrease in the expression of TGF-?1 in bronchoalveolar lavage fluid (BALF), peripheral blood and splenocytes. The injection of a virus expressing short hairpin PPAR-? into mice following LPS treatment resulted in a dose-dependent increase in lung resistance index and decrease in dynamic compliance, and a significant increase in BALF protein, which indicated PPAR-? was essential for the recovery of lung function following ALI. Of note, the serum expression of PPAR-? was inversely correlated with TGF-?1 and negatively correlated with disease severity in patients with ARDS. These data suggested that PPAR-? was essential for the recovery of lung function following ALI by the suppression of TGF-?1, which reveals a previously unappreciated mechanism controlling post-ALI lung recovery. äPPAR-? improves the recovery of lung function following acute respirat(epmc).pdf DeepDyve Pubget Overpricing