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10.1186/s12974-017-0897-3 http://scihub22266oqcxt.onion/10.1186/s12974-017-0897-3 C5481915!5481915!28645333     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Neuroinflammation 2017 ; 14 (ä): ä Nephropedia Template TP {{tp|p=28645333|t=2017. Sac-1004, a vascular leakage blocker, reduces cerebral ischemia?reperfusion injury by suppressing blood?brain barrier disruption and inflammation |pdf=|usr=}}{{28645333}} gab.com Text Sac-1004, a vascular leakage blocker, reduces cerebral ischemia reperfusion injury by suppressing blood brain barrier disruption and inflammation JO: J Neuroinflammation http://www.kidney.de/pget.php?&tw=1&pmid=28645333 #FOAvip Background: Blood?brain barrier (BBB) breakdown and inflammation are critical events in ischemic stroke, contributing to aggravated brain damage. The BBB mainly consists of microvascular endothelial cells sealed by tight junctions to protect the brain from blood-borne substances. Thus, the maintenance of BBB integrity may be a potential target for neuroprotection. Sac-1004, a pseudo-sugar derivative of cholesterol, enhances the endothelial barrier by the stabilization of the cortical actin ring. Results: Here, we report on the protective effects of Sac-1004 on cerebral ischemia-reperfusion (I/R) injury. Treatment with Sac-1004 significantly blocked the interleukin-1?-induced monolayer hyperpermeability of human brain microvascular endothelial cells (HBMECs), loss of tight junctions, and formation of actin stress fiber. Sac-1004 suppressed the expression of adhesion molecules, adhesion of U937 cells, and activation of nuclear factor-?B in HBMECs. Using a rat model of transient focal cerebral ischemia, it was shown that Sac-1004 effectively ameliorated neurological deficits and ischemic damage. In addition, Sac-1004 decreased BBB leakage and rescued tight junction-related proteins. Moreover, the staining of CD11b and glial fibrillary acidic protein showed that Sac-1004 inhibited glial activation. Conclusions: Taken together, these results demonstrate that Sac-1004 has neuroprotective activities through maintaining BBB integrity, suggesting that it is a great therapeutic candidate for stroke. Electronic supplementary material: The online version of this article (doi:10.1186/s12974-017-0897-3) contains supplementary material, which is available to authorized users. Twit Text FOAVip Sac-1004, a vascular leakage blocker, reduces cerebral ischemia reperfusion injury by suppressing blood brain barrier disruption and inflammation ????J Neuroinflammation http://www.kidney.de/pget.php?&tw=1&pmid=28645333 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28645333 #FOAvip English Wikipedia <ref>{{Cite pmid|28645333}}</ref> Sac-1004, a vascular leakage blocker, reduces cerebral ischemia?reperfusion injury by suppressing blood?brain barrier disruption and inflammation #MMPMID28645333 Zhang H; Park JH; Maharjan S; Park JA; Choi KS; Park H; Jeong Y; Ahn JH; Kim IH; Lee JC; Cho JH; Lee IK; Lee CH; Hwang IK; Kim YM; Suh YG; Won MH; Kwon YG J Neuroinflammation 2017[]; 14 (ä): ä PMID28645333show ga Background: Blood?brain barrier (BBB) breakdown and inflammation are critical events in ischemic stroke, contributing to aggravated brain damage. The BBB mainly consists of microvascular endothelial cells sealed by tight junctions to protect the brain from blood-borne substances. Thus, the maintenance of BBB integrity may be a potential target for neuroprotection. Sac-1004, a pseudo-sugar derivative of cholesterol, enhances the endothelial barrier by the stabilization of the cortical actin ring. Results: Here, we report on the protective effects of Sac-1004 on cerebral ischemia-reperfusion (I/R) injury. Treatment with Sac-1004 significantly blocked the interleukin-1?-induced monolayer hyperpermeability of human brain microvascular endothelial cells (HBMECs), loss of tight junctions, and formation of actin stress fiber. Sac-1004 suppressed the expression of adhesion molecules, adhesion of U937 cells, and activation of nuclear factor-?B in HBMECs. Using a rat model of transient focal cerebral ischemia, it was shown that Sac-1004 effectively ameliorated neurological deficits and ischemic damage. In addition, Sac-1004 decreased BBB leakage and rescued tight junction-related proteins. Moreover, the staining of CD11b and glial fibrillary acidic protein showed that Sac-1004 inhibited glial activation. Conclusions: Taken together, these results demonstrate that Sac-1004 has neuroprotective activities through maintaining BBB integrity, suggesting that it is a great therapeutic candidate for stroke. Electronic supplementary material: The online version of this article (doi:10.1186/s12974-017-0897-3) contains supplementary material, which is available to authorized users. äSac-1004, a vascular leakage blocker, reduces cerebral ischemia?reperf(epmc).pdf DeepDyve Pubget Overpricing