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10.4155/fsoa-2017-0002 http://scihub22266oqcxt.onion/10.4155/fsoa-2017-0002 C5481853!5481853!28670475     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28670475&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Future+Sci+OA 2017 ; 3 (2): ä Nephropedia Template TP {{tp|p=28670475|t=2017. The ascendance of microphysiological systems to solve the drug testing dilemma |pdf=|usr=}}{{28670475}} gab.com Text The ascendance of microphysiological systems to solve the drug testing dilemma JO: Future Sci OA http://www.kidney.de/pget.php?&tw=1&pmid=28670475 #FOAvip The development of drugs is a process obstructed with manifold security and efficacy concerns. Although animal models are still widely used to meet the diligence required, they are regarded as outdated tools with limited predictability. Novel microphysiological systems intend to create systemic models of human biology. Their ability to host 3D organoid constructs in a controlled microenvironment with mechanical and electrophysiological stimuli enables them to create and maintain homeostasis. These platforms are, thus, envisioned to be superior tools for testing and developing substances such as drugs, cosmetics and chemicals. We will present reasons why microphysiological systems are required for the emerging demands, highlight current technological and regulatory obstacles, and depict possible solutions from state-of-the-art platforms from major contributors. Twit Text FOAVip The ascendance of microphysiological systems to solve the drug testing dilemma ????Future Sci OA http://www.kidney.de/pget.php?&tw=1&pmid=28670475 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28670475 #FOAvip English Wikipedia <ref>{{Cite pmid|28670475}}</ref> The ascendance of microphysiological systems to solve the drug testing dilemma #MMPMID28670475 Dehne EM; Hasenberg T; Marx U Future Sci OA 2017[Jun]; 3 (2): ä PMID28670475show ga The development of drugs is a process obstructed with manifold security and efficacy concerns. Although animal models are still widely used to meet the diligence required, they are regarded as outdated tools with limited predictability. Novel microphysiological systems intend to create systemic models of human biology. Their ability to host 3D organoid constructs in a controlled microenvironment with mechanical and electrophysiological stimuli enables them to create and maintain homeostasis. These platforms are, thus, envisioned to be superior tools for testing and developing substances such as drugs, cosmetics and chemicals. We will present reasons why microphysiological systems are required for the emerging demands, highlight current technological and regulatory obstacles, and depict possible solutions from state-of-the-art platforms from major contributors. äThe ascendance of microphysiological systems to solve the drug testing(epmc).pdf DeepDyve Pubget Overpricing