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10.1038/ncomms15870 http://scihub22266oqcxt.onion/10.1038/ncomms15870 C5481840!5481840 !28627514     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28627514 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2017 ; 8 (ä): 15870 Nephropedia Template TP {{tp|p=28627514 |t=2017. Simultaneous overactivation of Wnt/?-catenin and TGF? signalling by miR-128-3p confers chemoresistance-associated metastasis in NSCLC |pdf=|usr=}}{{28627514 }} gab.com Text Simultaneous overactivation of Wnt/ -catenin and TGF signalling by miR-128-3p confers chemoresistance-associated metastasis in NSCLC JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28627514 #FOAvip Cancer chemoresistance and metastasis are tightly associated features. However, whether they share common molecular mechanisms and thus can be targeted with one common strategy remain unclear in non-small cell lung cancer (NSCLC). Here, we report that high levels of microRNA-128-3p (miR-128-3p) is key to concomitant development of chemoresistance and metastasis in residual NSCLC cells having survived repeated chemotherapy and correlates with chemoresistance, aggressiveness and poor prognosis in NSCLC patients. Mechanistically, miR-128-3p induces mesenchymal and stemness-like properties through downregulating multiple inhibitors of Wnt/?-catenin and TGF-? pathways, leading to their overactivation. Importantly, antagonism of miR-128-3p potently reverses metastasis and chemoresistance of highly malignant NSCLC cells, which could be completely reversed by restoring Wnt/?-catenin and TGF-? activities. Notably, correlations among miR-128-3p levels, activated ?-catenin and TGF-? signalling, and pro-epithelial-to-mesenchymal transition/pro-metastatic protein levels are validated in NSCLC patient specimens. These findings suggest that miR-128-3p might be a potential target against both metastasis and chemoresistance in NSCLC. Twit Text FOAVip Simultaneous overactivation of Wnt/ -catenin and TGF signalling by miR-128-3p confers chemoresistance-associated metastasis in NSCLC ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28627514 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28627514 #FOAvip English Wikipedia <ref>{{Cite pmid|28627514 }}</ref> Simultaneous overactivation of Wnt/?-catenin and TGF? signalling by miR-128-3p confers chemoresistance-associated metastasis in NSCLC #MMPMID28627514 Cai J ; Fang L ; Huang Y ; Li R ; Xu X ; Hu Z ; Zhang L ; Yang Y ; Zhu X ; Zhang H ; Wu J ; Huang Y ; Li J ; Zeng M ; Song E ; He Y ; Zhang L ; Li M Nat Commun 2017[Jun]; 8 (ä): 15870 PMID28627514 show ga Cancer chemoresistance and metastasis are tightly associated features. However, whether they share common molecular mechanisms and thus can be targeted with one common strategy remain unclear in non-small cell lung cancer (NSCLC). Here, we report that high levels of microRNA-128-3p (miR-128-3p) is key to concomitant development of chemoresistance and metastasis in residual NSCLC cells having survived repeated chemotherapy and correlates with chemoresistance, aggressiveness and poor prognosis in NSCLC patients. Mechanistically, miR-128-3p induces mesenchymal and stemness-like properties through downregulating multiple inhibitors of Wnt/?-catenin and TGF-? pathways, leading to their overactivation. Importantly, antagonism of miR-128-3p potently reverses metastasis and chemoresistance of highly malignant NSCLC cells, which could be completely reversed by restoring Wnt/?-catenin and TGF-? activities. Notably, correlations among miR-128-3p levels, activated ?-catenin and TGF-? signalling, and pro-epithelial-to-mesenchymal transition/pro-metastatic protein levels are validated in NSCLC patient specimens. These findings suggest that miR-128-3p might be a potential target against both metastasis and chemoresistance in NSCLC. |Animals [MESH] |Carcinoma, Non-Small-Cell Lung/*drug therapy/metabolism/mortality/pathology [MESH] |Cell Line, Tumor [MESH] |Drug Resistance, Neoplasm [MESH] |Epithelial-Mesenchymal Transition/genetics [MESH] |Female [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Humans [MESH] |Lung Neoplasms/*drug therapy/metabolism/mortality/pathology [MESH] |Male [MESH] |Mice, Inbred BALB C [MESH] |MicroRNAs/*metabolism [MESH] |Middle Aged [MESH] |Signal Transduction/drug effects/genetics [MESH] |Transforming Growth Factor beta/genetics/*metabolism [MESH] |Wnt Signaling Pathway [MESH] |Xenograft Model Antitumor Assays [MESH]Simultaneous overactivation of Wnt/?-catenin and TGF? signalling by mi(epmc).pdf DeepDyve Pubget Overpricing