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Integrative approach in the era of failing drug discovery and development #MMPMID28664100
Earm K; Earm YE
Integr Med Res 2014[Dec]; 3 (4): 211-6 PMID28664100show ga
The productivity decline in drug discovery and development is mainly caused by two factors; higher regulatory hurdles and low-hanging fruits being all picked. In addition, the recent target-based approach is thought to be increasing the price of innovation. Although target-based approach had many successes, a postreductionism method, which is systems biology, is on the rise. In this review, we discuss the foundations of two distinct approaches in finding a new drug.