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10.1262/jrd.2016-157 http://scihub22266oqcxt.onion/10.1262/jrd.2016-157 C5481636!5481636!28381667     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Reprod+Dev 2017 ; 63 (3): 325-32 Nephropedia Template TP {{tp|p=28381667|t=2017. Decrease of lactogenic hormones induce epithelial-mesenchymal transition via TGF?1 and arachidonic acid during mammary gland involution |pdf=|usr=}}{{28381667}} gab.com Text Decrease of lactogenic hormones induce epithelial-mesenchymal transition via TGF 1 and arachidonic acid during mammary gland involution JO: J Reprod Dev http://www.kidney.de/pget.php?&tw=1&pmid=28381667 #FOAvip During mammary gland involution, the epithelial mesenchymal transition (EMT) process plays an important role in tissue remodelling and in the termination of milk production. Transforming growth factor ? (TGF?) has been known as a central inducer to EMT and contributor to the mammary gland involution. However, the whole mechanism has accomplished the EMT process in mammary gland is still unclear. Here, we show that arachidonic acid, one of the major products in milk, is new player to control the EMT together with TGF? during mammary gland involution. Firstly, we observed decrease in CDH1 (epithelial marker gene) expression and increases in VIM and TWIST1 (mesenchymal marker genes), TGFB1, and PLCG2 (arachidonic acid synthesis gene) at involution. In epithelial cells culture experiments, depletion of lactogenic hormones to mimic the involution induced TGF?1 and PLCG2 expressions. Treatment with arachidonic acid in epithelial cells increased VIM and TWIST1 expressions without decrease of CDH1 expression, while TGF?1 decreased CDH1 and increased VIM and TWIST1; more importantly, TGF?1 induced the expression of PLCG2, but arachidonic acid did not induce the expression of TGFB1. Finally, arachidonic acid accelerated the TGF?1 increasing VIM and TWIST1 expressions, meanwhile arachidonic acid synthase inhibitor partially blocked the TGF?1 increasing VIM and TWIST1 expressions. In conclusion, TGF?1 stimulates arachidonic acid synthesis and the arachidonic acid has a function to postulate the EMT process together with TGF?1 during mammary gland involution. Twit Text FOAVip Decrease of lactogenic hormones induce epithelial-mesenchymal transition via TGF 1 and arachidonic acid during mammary gland involution ????J Reprod Dev http://www.kidney.de/pget.php?&tw=1&pmid=28381667 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28381667 #FOAvip English Wikipedia <ref>{{Cite pmid|28381667}}</ref> Decrease of lactogenic hormones induce epithelial-mesenchymal transition via TGF?1 and arachidonic acid during mammary gland involution #MMPMID28381667 ZHANG H; LIU Y; WENG J; USUDA K; FUJII K; WATANABE G; NAGAOKA K J Reprod Dev 2017[Jun]; 63 (3): 325-32 PMID28381667show ga During mammary gland involution, the epithelial mesenchymal transition (EMT) process plays an important role in tissue remodelling and in the termination of milk production. Transforming growth factor ? (TGF?) has been known as a central inducer to EMT and contributor to the mammary gland involution. However, the whole mechanism has accomplished the EMT process in mammary gland is still unclear. Here, we show that arachidonic acid, one of the major products in milk, is new player to control the EMT together with TGF? during mammary gland involution. Firstly, we observed decrease in CDH1 (epithelial marker gene) expression and increases in VIM and TWIST1 (mesenchymal marker genes), TGFB1, and PLCG2 (arachidonic acid synthesis gene) at involution. In epithelial cells culture experiments, depletion of lactogenic hormones to mimic the involution induced TGF?1 and PLCG2 expressions. Treatment with arachidonic acid in epithelial cells increased VIM and TWIST1 expressions without decrease of CDH1 expression, while TGF?1 decreased CDH1 and increased VIM and TWIST1; more importantly, TGF?1 induced the expression of PLCG2, but arachidonic acid did not induce the expression of TGFB1. Finally, arachidonic acid accelerated the TGF?1 increasing VIM and TWIST1 expressions, meanwhile arachidonic acid synthase inhibitor partially blocked the TGF?1 increasing VIM and TWIST1 expressions. In conclusion, TGF?1 stimulates arachidonic acid synthesis and the arachidonic acid has a function to postulate the EMT process together with TGF?1 during mammary gland involution. äDecrease of lactogenic hormones induce epithelial-mesenchymal transiti(epmc).pdf DeepDyve Pubget Overpricing