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10.1038/onc.2016.497 http://scihub22266oqcxt.onion/10.1038/onc.2016.497 C5481486!5481486 !28114280     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28114280 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncogene 2017 ; 36 (25 ): 3541-3552 Nephropedia Template TP {{tp|p=28114280 |t=2017. RARRES2 functions as a tumor suppressor by promoting ?-catenin phosphorylation/degradation and inhibiting p38 phosphorylation in adrenocortical carcinoma |pdf=|usr=}}{{28114280 }} gab.com Text RARRES2 functions as a tumor suppressor by promoting -catenin phosphorylation/degradation and inhibiting p38 phosphorylation in adrenocortical carcinoma JO: Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=28114280 #FOAvip Tumor suppressor genes and the immune system are critical players in inhibiting cancer initiation and/or progression. However, little is known about whether a tumor suppressor gene can function through both immune-dependent and -independent mechanisms. Retinoic acid receptor responder 2 (RARRES2) is transcriptionally downregulated in multiple cancer types. Previous studies suggested that it can serve as an immune-dependent tumor suppressor by acting as a chemoattractant to recruit anticancer immune cells expressing its receptor, the chemerin chemokine receptor 1 (CMKLR1), to sites of tumor. In this study, we investigated the role of RARRES2 in adrenocortical carcinoma (ACC), a rare lethal malignancy in which aberrant Wnt/?-catenin signaling is frequently detected. We show that RARRES2 expression is downregulated in ACC as compared with normal and benign adrenocortical tissues, which is a result of CpG hypermethylation. Despite minimal CMKLR1 expression and lack of phenotypic tumor-suppressive effect with exogenous RARRES2 treatment, RARRES2 overexpression in ACC cell lines not only reduced cell proliferation, cell invasion and tumorigenicity in vitro, but also inhibited tumor growth in vivo in two immunodeficient mouse xenograft models. Mechanistically, RARRES2 overexpression in ACC cells inhibited Wnt/?-catenin pathway activity by promoting ?-catenin phosphorylation and degradation, it also inhibited the phosphorylation of p38 mitogen-activated protein kinase. Thus our study identifies RARRES2 as a novel tumor suppressor for ACC, which can function through an immune-independent mechanism. Twit Text FOAVip RARRES2 functions as a tumor suppressor by promoting -catenin phosphorylation/degradation and inhibiting p38 phosphorylation in adrenocortical carcinoma ????Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=28114280 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28114280 #FOAvip English Wikipedia <ref>{{Cite pmid|28114280 }}</ref> RARRES2 functions as a tumor suppressor by promoting ?-catenin phosphorylation/degradation and inhibiting p38 phosphorylation in adrenocortical carcinoma #MMPMID28114280 Liu-Chittenden Y ; Jain M ; Gaskins K ; Wang S ; Merino MJ ; Kotian S ; Kumar Gara S ; Davis S ; Zhang L ; Kebebew E Oncogene 2017[Jun]; 36 (25 ): 3541-3552 PMID28114280 show ga Tumor suppressor genes and the immune system are critical players in inhibiting cancer initiation and/or progression. However, little is known about whether a tumor suppressor gene can function through both immune-dependent and -independent mechanisms. Retinoic acid receptor responder 2 (RARRES2) is transcriptionally downregulated in multiple cancer types. Previous studies suggested that it can serve as an immune-dependent tumor suppressor by acting as a chemoattractant to recruit anticancer immune cells expressing its receptor, the chemerin chemokine receptor 1 (CMKLR1), to sites of tumor. In this study, we investigated the role of RARRES2 in adrenocortical carcinoma (ACC), a rare lethal malignancy in which aberrant Wnt/?-catenin signaling is frequently detected. We show that RARRES2 expression is downregulated in ACC as compared with normal and benign adrenocortical tissues, which is a result of CpG hypermethylation. Despite minimal CMKLR1 expression and lack of phenotypic tumor-suppressive effect with exogenous RARRES2 treatment, RARRES2 overexpression in ACC cell lines not only reduced cell proliferation, cell invasion and tumorigenicity in vitro, but also inhibited tumor growth in vivo in two immunodeficient mouse xenograft models. Mechanistically, RARRES2 overexpression in ACC cells inhibited Wnt/?-catenin pathway activity by promoting ?-catenin phosphorylation and degradation, it also inhibited the phosphorylation of p38 mitogen-activated protein kinase. Thus our study identifies RARRES2 as a novel tumor suppressor for ACC, which can function through an immune-independent mechanism. |*Proteolysis [MESH] |*Wnt Signaling Pathway [MESH] |Adrenal Cortex Neoplasms/genetics/*metabolism [MESH] |Adrenocortical Carcinoma/genetics/*metabolism [MESH] |Animals [MESH] |Cell Line, Tumor [MESH] |Chemokines/genetics/*metabolism [MESH] |Female [MESH] |Heterografts [MESH] |Humans [MESH] |Intercellular Signaling Peptides and Proteins/genetics/*metabolism [MESH] |Male [MESH] |Mice [MESH] |Neoplasm Transplantation [MESH] |Phosphorylation/genetics [MESH] |Tumor Suppressor Proteins/genetics/*metabolism [MESH] |beta Catenin/genetics/*metabolism [MESH]RARRES2 functions as a tumor suppressor by promoting ?-catenin phosp(epmc).pdf DeepDyve Pubget Overpricing