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10.1038/s41598-017-04317-0 http://scihub22266oqcxt.onion/10.1038/s41598-017-04317-0 C5481439!5481439!28642549     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28642549|t=2017. Focal Adhesion Kinase Regulates Hepatic Stellate Cell Activation and Liver Fibrosis |pdf=|usr=}}{{28642549}} gab.com Text Focal Adhesion Kinase Regulates Hepatic Stellate Cell Activation and Liver Fibrosis JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28642549 #FOAvip Understanding the underlying molecular mechanisms of liver fibrosis is important to develop effective therapy. Herein, we show that focal-adhesion-kinse (FAK) plays a key role in promoting hepatic stellate cells (HSCs) activation in vitro and liver fibrosis progression in vivo. FAK activation is associated with increased expression of ?-smooth muscle actin (?-SMA) and collagen in fibrotic live tissues. Transforming growth factor beta-1 (TGF-?1) induces FAK activation in a time and dose dependent manner. FAK activation precedes the ?-SMA expression in HSCs. Inhibition of FAK activation blocks the ?-SMA and collagen expression, and inhibits the formation of stress fibers in TGF-?1 treated HSCs. Furthermore, inhibition of FAK activation significantly reduces HSC migration and small GTPase activation, and induces apoptotic signaling in TGF-?1 treated HSCs. Importantly, FAK inhibitor attenuates liver fibrosis in vivo and significantly reduces collagen and ?-SMA expression in an animal model of liver fibrosis. These data demonstrate that FAK plays an essential role in HSC activation and liver fibrosis progression, and FAK signaling pathway could be a potential target for liver fibrosis. Twit Text FOAVip Focal Adhesion Kinase Regulates Hepatic Stellate Cell Activation and Liver Fibrosis ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28642549 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28642549 #FOAvip English Wikipedia <ref>{{Cite pmid|28642549}}</ref> Focal Adhesion Kinase Regulates Hepatic Stellate Cell Activation and Liver Fibrosis #MMPMID28642549 Zhao XK; Yu L; Cheng ML; Che P; Lu YY; Zhang Q; Mu M; Li H; Zhu LL; Zhu JJ; Hu M; Li P; Liang YD; Luo XH; Cheng YJ; Xu ZX; Ding Q Sci Rep 2017[]; 7 (ä): ä PMID28642549show ga Understanding the underlying molecular mechanisms of liver fibrosis is important to develop effective therapy. Herein, we show that focal-adhesion-kinse (FAK) plays a key role in promoting hepatic stellate cells (HSCs) activation in vitro and liver fibrosis progression in vivo. FAK activation is associated with increased expression of ?-smooth muscle actin (?-SMA) and collagen in fibrotic live tissues. Transforming growth factor beta-1 (TGF-?1) induces FAK activation in a time and dose dependent manner. FAK activation precedes the ?-SMA expression in HSCs. Inhibition of FAK activation blocks the ?-SMA and collagen expression, and inhibits the formation of stress fibers in TGF-?1 treated HSCs. Furthermore, inhibition of FAK activation significantly reduces HSC migration and small GTPase activation, and induces apoptotic signaling in TGF-?1 treated HSCs. Importantly, FAK inhibitor attenuates liver fibrosis in vivo and significantly reduces collagen and ?-SMA expression in an animal model of liver fibrosis. These data demonstrate that FAK plays an essential role in HSC activation and liver fibrosis progression, and FAK signaling pathway could be a potential target for liver fibrosis. äFocal Adhesion Kinase Regulates Hepatic Stellate Cell Activation and L(epmc).pdf DeepDyve Pubget Overpricing