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10.1371/journal.pntd.0005655 http://scihub22266oqcxt.onion/10.1371/journal.pntd.0005655 C5481143!5481143!28604797     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+Negl+Trop+Dis 2017 ; 11 (6): ä Nephropedia Template TP {{tp|p=28604797|t=2017. A human inferred germline antibody binds to an immunodominant epitope and neutralizes Zika virus |pdf=|usr=}}{{28604797}} gab.com Text A human inferred germline antibody binds to an immunodominant epitope and neutralizes Zika virus JO: PLoS Negl Trop Dis http://www.kidney.de/pget.php?&tw=1&pmid=28604797 #FOAvip The isolation of neutralizing monoclonal antibodies (nmAbs) against the Zika virus (ZIKV) might lead to novel preventative strategies for infections in at-risk individuals, primarily pregnant women. Here we describe the characterization of human mAbs from the plasmablasts of an acutely infected patient. One of the 18 mAbs had the unusual feature of binding to and neutralizing ZIKV despite not appearing to have been diversified by affinity maturation. This mAb neutralized ZIKV (Neut50 ~ 2 ?g/ml) but did not react with any of the four dengue virus serotypes. Except for the expected junctional diversity created by the joining of the V-(D)-J genes, there was no deviation from immunoglobulin germline genes. This is a rare example of a human mAb with neutralizing activity in the absence of detectable somatic hypermutation. Importantly, binding of this mAb to ZIKV was specifically inhibited by human plasma from ZIKV-exposed individuals, suggesting that it may be of value in a diagnostic setting. Twit Text FOAVip A human inferred germline antibody binds to an immunodominant epitope and neutralizes Zika virus ????PLoS Negl Trop Dis http://www.kidney.de/pget.php?&tw=1&pmid=28604797 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28604797 #FOAvip English Wikipedia <ref>{{Cite pmid|28604797}}</ref> A human inferred germline antibody binds to an immunodominant epitope and neutralizes Zika virus #MMPMID28604797 Magnani DM; Silveira CGT; Rosen BC; Ricciardi MJ; Pedreño-Lopez N; Gutman MJ; Bailey VK; Maxwell HS; Domingues A; Gonzalez-Nieto L; Avelino-Silva VI; Trindade M; Nogueira J; Oliveira CS; Maestri A; Felix AC; Levi JE; Nogueira ML; Martins MA; Martinez-Navio JM; Fuchs SP; Whitehead SS; Burton DR; Desrosiers RC; Kallas EG; Watkins DI PLoS Negl Trop Dis 2017[Jun]; 11 (6): ä PMID28604797show ga The isolation of neutralizing monoclonal antibodies (nmAbs) against the Zika virus (ZIKV) might lead to novel preventative strategies for infections in at-risk individuals, primarily pregnant women. Here we describe the characterization of human mAbs from the plasmablasts of an acutely infected patient. One of the 18 mAbs had the unusual feature of binding to and neutralizing ZIKV despite not appearing to have been diversified by affinity maturation. This mAb neutralized ZIKV (Neut50 ~ 2 ?g/ml) but did not react with any of the four dengue virus serotypes. Except for the expected junctional diversity created by the joining of the V-(D)-J genes, there was no deviation from immunoglobulin germline genes. This is a rare example of a human mAb with neutralizing activity in the absence of detectable somatic hypermutation. Importantly, binding of this mAb to ZIKV was specifically inhibited by human plasma from ZIKV-exposed individuals, suggesting that it may be of value in a diagnostic setting. äA human inferred germline antibody binds to an immunodominant epitope (epmc).pdf DeepDyve Pubget Overpricing