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10.1038/nrclinonc.2016.217 http://scihub22266oqcxt.onion/10.1038/nrclinonc.2016.217 C5480600!5480600!28117416     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Rev+Clin+Oncol 2017 ; 14 (7): 399-416 Nephropedia Template TP {{tp|p=28117416|t=2017. Tumor-Associated Macrophages as Treatment Targets in Oncology |pdf=|usr=}}{{28117416}} gab.com Text Tumor-Associated Macrophages as Treatment Targets in Oncology JO: Nat Rev Clin Oncol http://www.kidney.de/pget.php?&tw=1&pmid=28117416 #FOAvip Macrophages are crucial drivers of tumor-promoting inflammation. Tumor-associated macrophages (TAM) contribute to tumor progression at different levels, including promoting genetic instability, nurturing cancer stem cells, paving the way to metastasis, taming protective adaptive immunity. TAM can exert a dual, yin yang influence on the effectiveness of cytoreductive therapies (chemotherapy and radiotherapy), antagonizing antitumor activity by orchestrating a tumor-promoting, tissue repair response or, instead, contributing to their ultimate antineoplastic efficacy. TAM express triggers of checkpoints of T cell activation and are targets of checkpoint blockade immunotherapy. Macrophage-centered therapeutic approaches include: strategies to block recruitment and survival in tumors; functional reeducation to an antitumor, M1-like mode; tumor-directed monoclonal antibodies which elicit extracellular killing or phagocytosis of cancer cells. We surmise that TAM can provide tools to tailor cytoreductive therapies and immunotherapy and that TAM-centered therapeutic strategies have the potential to complement and synergize with chemotherapy and immunotherapy. Twit Text FOAVip Tumor-Associated Macrophages as Treatment Targets in Oncology ????Nat Rev Clin Oncol http://www.kidney.de/pget.php?&tw=1&pmid=28117416 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28117416 #FOAvip English Wikipedia <ref>{{Cite pmid|28117416}}</ref> Tumor-Associated Macrophages as Treatment Targets in Oncology #MMPMID28117416 Mantovani A; Marchesi F; Malesci A; Laghi L; Allavena P Nat Rev Clin Oncol 2017[Jul]; 14 (7): 399-416 PMID28117416show ga Macrophages are crucial drivers of tumor-promoting inflammation. Tumor-associated macrophages (TAM) contribute to tumor progression at different levels, including promoting genetic instability, nurturing cancer stem cells, paving the way to metastasis, taming protective adaptive immunity. TAM can exert a dual, yin yang influence on the effectiveness of cytoreductive therapies (chemotherapy and radiotherapy), antagonizing antitumor activity by orchestrating a tumor-promoting, tissue repair response or, instead, contributing to their ultimate antineoplastic efficacy. TAM express triggers of checkpoints of T cell activation and are targets of checkpoint blockade immunotherapy. Macrophage-centered therapeutic approaches include: strategies to block recruitment and survival in tumors; functional reeducation to an antitumor, M1-like mode; tumor-directed monoclonal antibodies which elicit extracellular killing or phagocytosis of cancer cells. We surmise that TAM can provide tools to tailor cytoreductive therapies and immunotherapy and that TAM-centered therapeutic strategies have the potential to complement and synergize with chemotherapy and immunotherapy. äTumor-Associated Macrophages as Treatment Targets in Oncology (epmc).pdf DeepDyve Pubget Overpricing