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10.1364/BOE.8.001803 http://scihub22266oqcxt.onion/10.1364/BOE.8.001803 C5480582!5480582 !28663867     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28663867 &cmd=llinks): Failed to open stream: HTTP request failed! 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Adaptive optics optical coherence tomography angiography for morphometric analysis of choriocapillaris Invited |pdf=|usr=}}{{28663867 }} gab.com Text Adaptive optics optical coherence tomography angiography for morphometric analysis of choriocapillaris Invited JO: Biomed Opt Express http://www.kidney.de/pget.php?&tw=1&pmid=28663867 #FOAvip Histological studies have shown that morphometric changes at the microscopic level of choriocapillaris (CC) occur with aging and disease onset, and therefore may be sensitive biomarkers of outer retinal health. However, visualizing CC at this level in the living human eye is challenging because its microvascular is tightly interconnected and weakly reflecting. In this study, we address these challenges by developing and validating a method based on adaptive optics optical coherence tomography with angiography (AO-OCTA) that provides the necessary 3D resolution and image contrast to visualize and quantify these microscopic details. The complex network of anastomotic CC capillaries was successfully imaged in nine healthy subjects (26 to 68 years of age) and at seven retinal eccentricities across the macula. Using these images, four fundamental morphometric parameters of CC were characterized: retinal pigment epithelium-to-CC depth separation (17.5 ± 2.1 µm), capillary diameter (17.4 ± 2.3 µm), normalized capillary density (0.53 ± 0.08), and capillary length per unit area (50.4 ± 9.5 mm(-1)). AO-OCTA results were consistent with histologic studies and, unlike OCTA, showed clear delineation of CC capillaries, a requirement for measuring three of the four morphometric parameters. Success in younger and older eyes establishes a path for testing aging and disease effects in larger populations. To the best of our knowledge, this is the first quantitative morphometry of choriocapillaris at the level of individual capillaries in the living human retina. Twit Text FOAVip Adaptive optics optical coherence tomography angiography for morphometric analysis of choriocapillaris Invited ????Biomed Opt Express http://www.kidney.de/pget.php?&tw=1&pmid=28663867 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28663867 #FOAvip English Wikipedia <ref>{{Cite pmid|28663867 }}</ref> Adaptive optics optical coherence tomography angiography for morphometric analysis of choriocapillaris Invited #MMPMID28663867 Kurokawa K ; Liu Z ; Miller DT Biomed Opt Express 2017[Mar]; 8 (3 ): 1803-1822 PMID28663867 show ga Histological studies have shown that morphometric changes at the microscopic level of choriocapillaris (CC) occur with aging and disease onset, and therefore may be sensitive biomarkers of outer retinal health. However, visualizing CC at this level in the living human eye is challenging because its microvascular is tightly interconnected and weakly reflecting. In this study, we address these challenges by developing and validating a method based on adaptive optics optical coherence tomography with angiography (AO-OCTA) that provides the necessary 3D resolution and image contrast to visualize and quantify these microscopic details. The complex network of anastomotic CC capillaries was successfully imaged in nine healthy subjects (26 to 68 years of age) and at seven retinal eccentricities across the macula. Using these images, four fundamental morphometric parameters of CC were characterized: retinal pigment epithelium-to-CC depth separation (17.5 ± 2.1 µm), capillary diameter (17.4 ± 2.3 µm), normalized capillary density (0.53 ± 0.08), and capillary length per unit area (50.4 ± 9.5 mm(-1)). AO-OCTA results were consistent with histologic studies and, unlike OCTA, showed clear delineation of CC capillaries, a requirement for measuring three of the four morphometric parameters. Success in younger and older eyes establishes a path for testing aging and disease effects in larger populations. To the best of our knowledge, this is the first quantitative morphometry of choriocapillaris at the level of individual capillaries in the living human retina. äAdaptive optics optical coherence tomography angiography for morphomet(epmc).pdf DeepDyve Pubget Overpricing