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10.1038/nri.2016.117 http://scihub22266oqcxt.onion/10.1038/nri.2016.117 C5480291!5480291!27890913     free     free     free       Nat+Rev+Immunol 2017 ; 17 (1): 7-20 Nephropedia Template TP {{tp|p=27890913|t=2017. Early local immune defenses in the respiratory tract |pdf=|usr=}}{{27890913}} gab.com Text Early local immune defenses in the respiratory tract JO: Nat Rev Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27890913 #FOAvip The respiratory immune response consists of multiple tiers of cellular responses that are engaged in a sequential manner in order to control infections. Stepwise engagement of effector functions with progressively increasing host fitness costs limits tissue damage. In addition, specific mechanisms are in place to promote disease tolerance in response to respiratory infections. Environmental factors, obesity and the ageing process can alter the efficiency and regulation of this tiered response, increasing pathology and mortality as a result. In this Review, we describe the cell types that coordinate pathogen clearance and tissue repair through serial secretion of cytokines, and discuss how the environment and comorbidity influence this response. Twit Text FOAVip Early local immune defenses in the respiratory tract ????Nat Rev Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27890913 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27890913 #FOAvip English Wikipedia <ref>{{Cite pmid|27890913}}</ref> Early local immune defenses in the respiratory tract #MMPMID27890913 Iwasaki A; Foxman EF; Molony RD Nat Rev Immunol 2017[Jan]; 17 (1): 7-20 PMID27890913show ga The respiratory immune response consists of multiple tiers of cellular responses that are engaged in a sequential manner in order to control infections. Stepwise engagement of effector functions with progressively increasing host fitness costs limits tissue damage. In addition, specific mechanisms are in place to promote disease tolerance in response to respiratory infections. Environmental factors, obesity and the ageing process can alter the efficiency and regulation of this tiered response, increasing pathology and mortality as a result. In this Review, we describe the cell types that coordinate pathogen clearance and tissue repair through serial secretion of cytokines, and discuss how the environment and comorbidity influence this response. äEarly local immune defenses in the respiratory tract (epmc).pdf DeepDyve Pubget Overpricing