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10.1128/mSphere.00343-16

http://scihub22266oqcxt.onion/10.1128/mSphere.00343-16
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C5480036!5480036!28656177
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suck abstract from ncbi


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pmid28656177      mSphere 2017 ; 2 (3): ä
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  • Giardia Colonizes and Encysts in High-Density Foci in the Murine Small Intestine #MMPMID28656177
  • Barash NR; Nosala C; Pham JK; McInally SG; Gourguechon S; McCarthy-Sinclair B; Dawson SC
  • mSphere 2017[May]; 2 (3): ä PMID28656177show ga
  • Giardia is a single-celled parasite causing significant diarrheal disease in several hundred million people worldwide. Due to limited access to the site of infection in the gastrointestinal tract, our understanding of the dynamics of Giardia infections in the host has remained limited and largely inferred from laboratory culture. To better understand Giardia physiology and colonization in the host, we developed imaging methods to quantify Giardia expressing bioluminescent physiological reporters in two relevant animal models. We discovered that parasites primarily colonize and encyst in the proximal small intestine in discrete, high-density foci. We also show that high parasite density contributes to encystation initiation.
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