Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/s41598-017-04183-w http://scihub22266oqcxt.onion/10.1038/s41598-017-04183-w C5479867!5479867 !28638138     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28638138 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 280.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 280.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 280.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 280.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28638138 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (1 ): 3997 Nephropedia Template TP {{tp|p=28638138 |t=2017. Immune regulation by oral tolerance induces alternate activation of macrophages and reduces markers of plaque destabilization in Apob(tm2Sgy)/Ldlr(tm1Her/J) mice |pdf=|usr=}}{{28638138 }} gab.com Text Immune regulation by oral tolerance induces alternate activation of macrophages and reduces markers of plaque destabilization in Apob(tm2Sgy)/Ldlr(tm1Her/J) mice JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28638138 #FOAvip Atherosclerosis is the leading cause for cardiovascular mortality. We determined the effect of multi-antigenic construct expressing three peptides AHC (ApoB100, HSP60 and outer membrane protein of chlamydia pneumonia) in stabilizing advanced atherosclerosis in Apob(tm2Sgy)/Ldlr(tm1Her/J) mice. Atherosclerosis was induced by feeding high fat diet (HFD) to mice for 10 weeks, followed by five oral dosing with purified AHC or ovalbumin on alternate days and continued on HFD for another 10 weeks. Tolerance was associated with significantly higher numbers of regulatory T cells both in aortic sinus and spleen with higher mRNA expression of CTLA4 (3 fold), Foxp3 (1.4 folds) and TGF-? (1.62) in aorta. Tregs cells were found to induce alternate activation of macrophages to M2 phenotype, with a reduction in plaque inflammation. AHC treatment showed evidence of plaque stabilization as observed by reduction in plaque necrosis in aortic sinus (35.8%) and in brachiocephalic artery (26%), with reduced expression of Tissue factor and MMP9. Macrophage apoptosis was reduced and collagen content was enhanced by treatment. Our results suggest that tolerance to atherogenic peptides increases regulatory T cells which activate M2 macrophages, prevent T cell proliferation and reduce plaque destabilization and inflammatory markers thus providing evidences for plaque stabilization in mice with advanced atherosclerosis. Twit Text FOAVip Immune regulation by oral tolerance induces alternate activation of macrophages and reduces markers of plaque destabilization in Apob(tm2Sgy)/Ldlr(tm1Her/J) mice ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28638138 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28638138 #FOAvip English Wikipedia <ref>{{Cite pmid|28638138 }}</ref> Immune regulation by oral tolerance induces alternate activation of macrophages and reduces markers of plaque destabilization in Apob(tm2Sgy)/Ldlr(tm1Her/J) mice #MMPMID28638138 Thota LN ; Ponnusamy T ; Philip S ; Lu X ; Mundkur L Sci Rep 2017[Jun]; 7 (1 ): 3997 PMID28638138 show ga Atherosclerosis is the leading cause for cardiovascular mortality. We determined the effect of multi-antigenic construct expressing three peptides AHC (ApoB100, HSP60 and outer membrane protein of chlamydia pneumonia) in stabilizing advanced atherosclerosis in Apob(tm2Sgy)/Ldlr(tm1Her/J) mice. Atherosclerosis was induced by feeding high fat diet (HFD) to mice for 10 weeks, followed by five oral dosing with purified AHC or ovalbumin on alternate days and continued on HFD for another 10 weeks. Tolerance was associated with significantly higher numbers of regulatory T cells both in aortic sinus and spleen with higher mRNA expression of CTLA4 (3 fold), Foxp3 (1.4 folds) and TGF-? (1.62) in aorta. Tregs cells were found to induce alternate activation of macrophages to M2 phenotype, with a reduction in plaque inflammation. AHC treatment showed evidence of plaque stabilization as observed by reduction in plaque necrosis in aortic sinus (35.8%) and in brachiocephalic artery (26%), with reduced expression of Tissue factor and MMP9. Macrophage apoptosis was reduced and collagen content was enhanced by treatment. Our results suggest that tolerance to atherogenic peptides increases regulatory T cells which activate M2 macrophages, prevent T cell proliferation and reduce plaque destabilization and inflammatory markers thus providing evidences for plaque stabilization in mice with advanced atherosclerosis. |Animals [MESH] |Aorta/drug effects/physiopathology [MESH] |Apolipoprotein B-100/*administration & dosage/genetics [MESH] |Atherosclerosis/*drug therapy/genetics/immunology/pathology [MESH] |Bacterial Outer Membrane Proteins/*administration & dosage/chemistry [MESH] |CTLA-4 Antigen/genetics [MESH] |Cell Proliferation/drug effects [MESH] |Chaperonin 60/*administration & dosage/genetics [MESH] |Chlamydophila pneumoniae/chemistry [MESH] |Diet, High-Fat/adverse effects [MESH] |Forkhead Transcription Factors/genetics [MESH] |Gene Expression Regulation/drug effects [MESH] |Humans [MESH] |Macrophages/drug effects/immunology [MESH] |Matrix Metalloproteinase 9/genetics [MESH] |Mice [MESH] |Peptides/*administration & dosage/genetics [MESH] |Sinus of Valsalva/drug effects/immunology [MESH] |Spleen/drug effects/immunology [MESH] |T-Lymphocytes, Regulatory/drug effects [MESH] |Thromboplastin/genetics [MESH]Immune regulation by oral tolerance induces alternate activation of ma(epmc).pdf DeepDyve Pubget Overpricing