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10.1126/sciadv.1603032 http://scihub22266oqcxt.onion/10.1126/sciadv.1603032 C5479650!5479650 !28691087     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28691087 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Adv 2017 ; 3 (6 ): e1603032 Nephropedia Template TP {{tp|p=28691087 |t=2017. Cytoskeletal actin dynamics shape a ramifying actin network underpinning immunological synapse formation |pdf=|usr=}}{{28691087 }} gab.com Text Cytoskeletal actin dynamics shape a ramifying actin network underpinning immunological synapse formation JO: Sci Adv http://www.kidney.de/pget.php?&tw=1&pmid=28691087 #FOAvip T cell activation and especially trafficking of T cell receptor microclusters during immunological synapse formation are widely thought to rely on cytoskeletal remodeling. However, important details on the involvement of actin in the latter transport processes are missing. Using a suite of advanced optical microscopes to analyze resting and activated T cells, we show that, following contact formation with activating surfaces, these cells sequentially rearrange their cortical actin across the entire cell, creating a previously unreported ramifying actin network above the immunological synapse. This network shows all the characteristics of an inward-growing transportation network and its dynamics correlating with T cell receptor rearrangements. This actin reorganization is accompanied by an increase in the nanoscale actin meshwork size and the dynamic adjustment of the turnover times and filament lengths of two differently sized filamentous actin populations, wherein formin-mediated long actin filaments support a very flat and stiff contact at the immunological synapse interface. The initiation of immunological synapse formation, as highlighted by calcium release, requires markedly little contact with activating surfaces and no cytoskeletal rearrangements. Our work suggests that incipient signaling in T cells initiates global cytoskeletal rearrangements across the whole cell, including a stiffening process for possibly mechanically supporting contact formation at the immunological synapse interface as well as a central ramified transportation network apparently directed at the consolidation of the contact and the delivery of effector functions. Twit Text FOAVip Cytoskeletal actin dynamics shape a ramifying actin network underpinning immunological synapse formation ????Sci Adv http://www.kidney.de/pget.php?&tw=1&pmid=28691087 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28691087 #FOAvip English Wikipedia <ref>{{Cite pmid|28691087 }}</ref> Cytoskeletal actin dynamics shape a ramifying actin network underpinning immunological synapse formation #MMPMID28691087 Fritzsche M ; Fernandes RA ; Chang VT ; Colin-York H ; Clausen MP ; Felce JH ; Galiani S ; Erlenkämper C ; Santos AM ; Heddleston JM ; Pedroza-Pacheco I ; Waithe D ; de la Serna JB ; Lagerholm BC ; Liu TL ; Chew TL ; Betzig E ; Davis SJ ; Eggeling C Sci Adv 2017[Jun]; 3 (6 ): e1603032 PMID28691087 show ga T cell activation and especially trafficking of T cell receptor microclusters during immunological synapse formation are widely thought to rely on cytoskeletal remodeling. However, important details on the involvement of actin in the latter transport processes are missing. Using a suite of advanced optical microscopes to analyze resting and activated T cells, we show that, following contact formation with activating surfaces, these cells sequentially rearrange their cortical actin across the entire cell, creating a previously unreported ramifying actin network above the immunological synapse. This network shows all the characteristics of an inward-growing transportation network and its dynamics correlating with T cell receptor rearrangements. This actin reorganization is accompanied by an increase in the nanoscale actin meshwork size and the dynamic adjustment of the turnover times and filament lengths of two differently sized filamentous actin populations, wherein formin-mediated long actin filaments support a very flat and stiff contact at the immunological synapse interface. The initiation of immunological synapse formation, as highlighted by calcium release, requires markedly little contact with activating surfaces and no cytoskeletal rearrangements. Our work suggests that incipient signaling in T cells initiates global cytoskeletal rearrangements across the whole cell, including a stiffening process for possibly mechanically supporting contact formation at the immunological synapse interface as well as a central ramified transportation network apparently directed at the consolidation of the contact and the delivery of effector functions. |*Cytoskeleton [MESH] |Actin Cytoskeleton/metabolism [MESH] |Actins/*metabolism [MESH] |Animals [MESH] |Biomarkers [MESH] |Cell Line [MESH] |Gene Rearrangement, T-Lymphocyte [MESH] |Humans [MESH] |Immunological Synapses/*metabolism [MESH] |Lymphocyte Activation [MESH] |Receptors, Antigen, T-Cell/genetics/metabolism [MESH] |Signal Transduction [MESH]Cytoskeletal actin dynamics shape a ramifying actin network underpinni(epmc).pdf DeepDyve Pubget Overpricing