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10.1146/annurev-nutr-071715-050711 http://scihub22266oqcxt.onion/10.1146/annurev-nutr-071715-050711 C5479634!5479634!27215587     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Annu+Rev+Nutr 2016 ; 36 (ä): 301-36 Nephropedia Template TP {{tp|p=27215587|t=2016. Sources and functions of extracellular small RNAs in human circulation |pdf=|usr=}}{{27215587}} gab.com Text Sources and functions of extracellular small RNAs in human circulation JO: Annu Rev Nutr http://www.kidney.de/pget.php?&tw=1&pmid=27215587 #FOAvip Various biotypes of endogenous small RNAs (sRNAs) have been detected in human circulation including microRNAs, tRNA, rRNA and yRNA fragments. These extracellular sRNAs (ex-sRNAs) are packaged and secreted by many different cell types. Ex-sRNAs exhibit differences in abundance in several disease contexts and have therefore been proposed as well-suited biomarkers. Furthermore, exosome-borne ex-sRNAs have been reported to elicit physiological responses in receiving cells. Albeit controversial, exogenous ex-sRNAs derived from plants and microorganisms have also been described in human blood. Essential questions which remain to be conclusively addressed in the field concern the (i) presence and mechanistic sources of exogenous ex-sRNA in human bodily fluids, (ii) detection and measurement of ex-sRNA in human circulation, (iii) selectivity of ex-sRNA export and import, (iv) sensitivity and specificity of ex-sRNA delivery to cellular targets, and (v) cell-, tissue-, organ- and organism-wide impacts of ex-sRNAs. We will survey the present state of knowledge of most of these questions in this review. Twit Text FOAVip Sources and functions of extracellular small RNAs in human circulation ????Annu Rev Nutr http://www.kidney.de/pget.php?&tw=1&pmid=27215587 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27215587 #FOAvip English Wikipedia <ref>{{Cite pmid|27215587}}</ref> Sources and functions of extracellular small RNAs in human circulation #MMPMID27215587 Fritz JV; Heintz-Buschart A; Ghosal A; Wampach L; Etheridge A; Galas D; Wilmes P Annu Rev Nutr 2016[Jul]; 36 (ä): 301-36 PMID27215587show ga Various biotypes of endogenous small RNAs (sRNAs) have been detected in human circulation including microRNAs, tRNA, rRNA and yRNA fragments. These extracellular sRNAs (ex-sRNAs) are packaged and secreted by many different cell types. Ex-sRNAs exhibit differences in abundance in several disease contexts and have therefore been proposed as well-suited biomarkers. Furthermore, exosome-borne ex-sRNAs have been reported to elicit physiological responses in receiving cells. Albeit controversial, exogenous ex-sRNAs derived from plants and microorganisms have also been described in human blood. Essential questions which remain to be conclusively addressed in the field concern the (i) presence and mechanistic sources of exogenous ex-sRNA in human bodily fluids, (ii) detection and measurement of ex-sRNA in human circulation, (iii) selectivity of ex-sRNA export and import, (iv) sensitivity and specificity of ex-sRNA delivery to cellular targets, and (v) cell-, tissue-, organ- and organism-wide impacts of ex-sRNAs. We will survey the present state of knowledge of most of these questions in this review. äSources and functions of extracellular small RNAs in human circulation(epmc).pdf DeepDyve Pubget Overpricing