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10.1007/s12664-016-0633-4

http://scihub22266oqcxt.onion/10.1007/s12664-016-0633-4
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suck abstract from ncbi


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pmid27053352      Indian+J+Gastroenterol 2016 ; 35 (2): 133-8
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  • Association between common variable immunodeficiency and collagenous infiltrative disorders of the gastrointestinal tract: A series of four patients #MMPMID27053352
  • Mandaliya R; Burkart AL; DiMarino AJ; Rattan S; Cohen S
  • Indian J Gastroenterol 2016[Mar]; 35 (2): 133-8 PMID27053352show ga
  • Hypogammaglobulinemia/common variable immunodeficiency (CVID) may lead to disruption of the gut mucosal immune barrier. Collagenous infiltrative disorders of the intestinal tract (colitis, gastritis, sprue) constitute a relatively new spectrum of gastrointestinal disorders. Our aims were (1) to determine the association between immunoglobulin deficiency state like CVID and collagenous infiltrative disorders of the gut and (2) to study the clinic-pathologic characteristics and treatment outcomes in these patients. A retrospective search was conducted to identify cases with concurrence of these two conditions at an academic center from 2007 to 2013. Four such patients were identified from our database: three with collagenous colitis and one with collagenous gastritis. All patients with collagenous colitis had normal colonic mucosa while the patient with collagenous gastritis had nodular gastric mucosa. Only one patient out of four had decreased plasma cells in the submucosa as expected in low immunoglobulin states. All patients had improvement in their symptoms on immunoglobulin therapy with considerable remission on budesonide. Literature search revealed reporting of four similar patients. In conclusion, (1) the association between collagenous infiltrative disorders of the gut and CVID and its prompt response to immunoglobulins with effective maintenance with budesonide are novel findings. Our study also shows that the presence of plasma cells should not rule out the possibility of CVID. (2) In patients with chronic diarrhea, hypogammaglobulinemia and collagenous colitis/sprue should be considered for the available effective treatments such as immunoglobulins and budesonide.
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