Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27053352
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27053352
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Indian+J+Gastroenterol
2016 ; 35
(2
): 133-8
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Association between common variable immunodeficiency and collagenous infiltrative
disorders of the gastrointestinal tract: A series of four patients
#MMPMID27053352
Mandaliya R
; Burkart AL
; DiMarino AJ
; Rattan S
; Cohen S
Indian J Gastroenterol
2016[Mar]; 35
(2
): 133-8
PMID27053352
show ga
Hypogammaglobulinemia/common variable immunodeficiency (CVID) may lead to
disruption of the gut mucosal immune barrier. Collagenous infiltrative disorders
of the intestinal tract (colitis, gastritis, sprue) constitute a relatively new
spectrum of gastrointestinal disorders. Our aims were (1) to determine the
association between immunoglobulin deficiency state like CVID and collagenous
infiltrative disorders of the gut and (2) to study the clinic-pathologic
characteristics and treatment outcomes in these patients. A retrospective search
was conducted to identify cases with concurrence of these two conditions at an
academic center from 2007 to 2013. Four such patients were identified from our
database: three with collagenous colitis and one with collagenous gastritis. All
patients with collagenous colitis had normal colonic mucosa while the patient
with collagenous gastritis had nodular gastric mucosa. Only one patient out of
four had decreased plasma cells in the submucosa as expected in low
immunoglobulin states. All patients had improvement in their symptoms on
immunoglobulin therapy with considerable remission on budesonide. Literature
search revealed reporting of four similar patients. In conclusion, (1) the
association between collagenous infiltrative disorders of the gut and CVID and
its prompt response to immunoglobulins with effective maintenance with budesonide
are novel findings. Our study also shows that the presence of plasma cells should
not rule out the possibility of CVID. (2) In patients with chronic diarrhea,
hypogammaglobulinemia and collagenous colitis/sprue should be considered for the
available effective treatments such as immunoglobulins and budesonide.
|Adult
[MESH]
|Aged
[MESH]
|Budesonide/administration & dosage/therapeutic use
[MESH]