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10.1016/j.cmet.2017.03.019 http://scihub22266oqcxt.onion/10.1016/j.cmet.2017.03.019 C5479132!5479132!28380384     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Metab 2017 ; 25 (4): 961-974.e4 Nephropedia Template TP {{tp|p=28380384|t=2017. Clock regulation of metabolites reveals coupling between transcription and metabolism |pdf=|usr=}}{{28380384}} gab.com Text Clock regulation of metabolites reveals coupling between transcription and metabolism JO: Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=28380384 #FOAvip The intricate connection between the circadian clock and metabolism remains poorly understood. We used high temporal resolution metabolite profiling to explore clock regulation of mouse liver and cell autonomous metabolism. In liver, ~50% of metabolites were circadian, with enrichment of nucleotide, amino acid, and methylation pathways. In U2 OS cells, 28% were circadian, including amino acids and NAD biosynthesis metabolites. Eighteen metabolites oscillated in both systems and a subset of these in primary hepatocytes. These 18 metabolites were enriched in methylation and amino acid pathways. To assess clock-dependence of these rhythms, we used genetic perturbation. BMAL1 knockdown diminished metabolite rhythms, while CRY1 or CRY2 perturbation generally shortened/lengthened rhythms, respectively. Surprisingly, CRY1 knockdown induced 8 h rhythms in amino acid, methylation, and vitamin metabolites, decoupling metabolite from transcriptional rhythms, with potential impact on nutrient sensing in vivo. These results provide the first comprehensive views of circadian liver and cell autonomous metabolism. Twit Text FOAVip Clock regulation of metabolites reveals coupling between transcription and metabolism ????Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=28380384 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28380384 #FOAvip English Wikipedia <ref>{{Cite pmid|28380384}}</ref> Clock regulation of metabolites reveals coupling between transcription and metabolism #MMPMID28380384 Krishnaiah SY; Wu G; Altman BJ; Growe J; Rhoades SD; Coldren F; Venkataraman A; Olarerin-George AO; Francey LJ; Mukherjee S; Girish S; Selby CP; Cal S; Ubeydullah E; Sianati B; Sengupta A; Anafi RC; Kavakli IH; Sancar A; Baur JA; Dang CV; Hogenesch JB; Weljie AM Cell Metab 2017[Apr]; 25 (4): 961-974.e4 PMID28380384show ga The intricate connection between the circadian clock and metabolism remains poorly understood. We used high temporal resolution metabolite profiling to explore clock regulation of mouse liver and cell autonomous metabolism. In liver, ~50% of metabolites were circadian, with enrichment of nucleotide, amino acid, and methylation pathways. In U2 OS cells, 28% were circadian, including amino acids and NAD biosynthesis metabolites. Eighteen metabolites oscillated in both systems and a subset of these in primary hepatocytes. These 18 metabolites were enriched in methylation and amino acid pathways. To assess clock-dependence of these rhythms, we used genetic perturbation. BMAL1 knockdown diminished metabolite rhythms, while CRY1 or CRY2 perturbation generally shortened/lengthened rhythms, respectively. Surprisingly, CRY1 knockdown induced 8 h rhythms in amino acid, methylation, and vitamin metabolites, decoupling metabolite from transcriptional rhythms, with potential impact on nutrient sensing in vivo. These results provide the first comprehensive views of circadian liver and cell autonomous metabolism. äClock regulation of metabolites reveals coupling between transcription(epmc).pdf DeepDyve Pubget Overpricing