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2017 ; 7
(2
): 119-121
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Neuroleptic malignant syndrome in the trauma intensive care unit: Diagnosis and
management of a rare disease in a challenging population
#MMPMID28660166
Drews JD
; Christopher A
; Evans DC
Int J Crit Illn Inj Sci
2017[Apr]; 7
(2
): 119-121
PMID28660166
show ga
Neuroleptic malignant syndrome (NMS) is a life-threatening neurological disorder
associated with the use of antipsychotic medications. Many of its classic signs,
such as fever and altered mental status, are nonspecific in trauma intensive care
unit (ICU) patients, and its rarity makes it a difficult diagnosis in this
population. However, delays in treatment can be costly both in terms of hospital
resources and patient outcomes. We herein report a case of a 54-year-old trauma
patient with NMS precipitated by a combination of cocaine withdrawal and
neuroleptic medications. Few cases of NMS in the intubated polytrauma patient
have been described in the literature previously. Given the poor outcomes
associated with this disorder, ICU patients would benefit from risk
stratification and avoidance of neuroleptic medications in those at highest risk
for NMS, particularly patients who are withdrawing from dopaminergic agents.