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10.1042/BSR20170002 http://scihub22266oqcxt.onion/10.1042/BSR20170002 C5479018!5479018!28536311     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28536311&cmd=llinks): Failed to open stream: HTTP request failed! 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Vascular endothelial growth factor modified macrophages transdifferentiate into endothelial-like cells and decrease foam cell formation |pdf=|usr=}}{{28536311}} gab.com Text Vascular endothelial growth factor modified macrophages transdifferentiate into endothelial-like cells and decrease foam cell formation JO: Biosci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28536311 #FOAvip Macrophages are largely involved in the whole process of atherosclerosis from an initiation lesion to an advanced lesion. Endothelial disruption is the initial step and macrophage-derived foam cells are the hallmark of atherosclerosis. Promotion of vascular integrity and inhibition of foam cell formation are two important strategies for preventing atherosclerosis. How can we inhibit even the reverse negative role of macrophages in atherosclerosis? The present study was performed to investigate if overexpressing endogenous human vascular endothelial growth factor (VEGF) could facilitate transdifferentiation of macrophages into endothelial-like cells (ELCs) and inhibit foam cell formation. We demonstrated that VEGF-modified macrophages which stably overexpressed human VEGF (hVEGF165) displayed a high capability to alter their phenotype and function into ELCs in vitro. Exogenous VEGF could not replace endogenous VEGF to induce the transdifferentiation of macrophages into ELCs in vitro. We further showed that VEGF-modified macrophages significantly decreased cytoplasmic lipid accumulation after treatment with oxidized LDL (ox-LDL). Moreover, down-regulation of CD36 expression in these cells was probably one of the mechanisms of reduction in foam cell formation. Our results provided the in vitro proof of VEGF-modified macrophages as atheroprotective therapeutic cells by both promotion of vascular repair and inhibition of foam cell formation. Twit Text FOAVip Vascular endothelial growth factor modified macrophages transdifferentiate into endothelial-like cells and decrease foam cell formation ????Biosci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28536311 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28536311 #FOAvip English Wikipedia <ref>{{Cite pmid|28536311}}</ref> Vascular endothelial growth factor modified macrophages transdifferentiate into endothelial-like cells and decrease foam cell formation #MMPMID28536311 Yan D; He Y; Dai J; Yang L; Wang X; Ruan Q Biosci Rep 2017[Jun]; 37 (3): ä PMID28536311show ga Macrophages are largely involved in the whole process of atherosclerosis from an initiation lesion to an advanced lesion. Endothelial disruption is the initial step and macrophage-derived foam cells are the hallmark of atherosclerosis. Promotion of vascular integrity and inhibition of foam cell formation are two important strategies for preventing atherosclerosis. How can we inhibit even the reverse negative role of macrophages in atherosclerosis? The present study was performed to investigate if overexpressing endogenous human vascular endothelial growth factor (VEGF) could facilitate transdifferentiation of macrophages into endothelial-like cells (ELCs) and inhibit foam cell formation. We demonstrated that VEGF-modified macrophages which stably overexpressed human VEGF (hVEGF165) displayed a high capability to alter their phenotype and function into ELCs in vitro. Exogenous VEGF could not replace endogenous VEGF to induce the transdifferentiation of macrophages into ELCs in vitro. We further showed that VEGF-modified macrophages significantly decreased cytoplasmic lipid accumulation after treatment with oxidized LDL (ox-LDL). Moreover, down-regulation of CD36 expression in these cells was probably one of the mechanisms of reduction in foam cell formation. Our results provided the in vitro proof of VEGF-modified macrophages as atheroprotective therapeutic cells by both promotion of vascular repair and inhibition of foam cell formation. äVascular endothelial growth factor modified macrophages transdifferent(epmc).pdf DeepDyve Pubget Overpricing