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2017 ; 2017
(ä): 7285656
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Lymphangiogenesis in Oral Squamous Cell Carcinoma: Correlation with VEGF-C
Expression and Lymph Node Metastasis
#MMPMID28680444
Abdul-Aziz MA
; Amin AK
; El-Rouby DH
; Shaker OG
Int J Dent
2017[]; 2017
(ä): 7285656
PMID28680444
show ga
BACKGROUND: Oral squamous cell carcinoma (OSCC) is the most common oral
malignancy that preferentially spreads to the cervical lymph node which, when
involved, complicates the anticancer therapy and threatens the patient life. It
was suggested that lymph node metastasis may be facilitated by lymphangiogenesis.
VEGF-C is one of the most important lymphangiogenic inducers that promotes the
lymphatic vessels growth and supports the survival of adult lymphatic endothelial
cells. METHODS: Lymphatic vessels density (LVD) and LV morphometry were digitally
evaluated using D2-40. The expression of VEGF-C was also assessed using
immunohistochemistry and real-time polymerase chain reaction in 6 normal oral
mucosa cases and 72 cases of OSCC. The correlation between LVD and LV
morphometry, VEGF-C, and lymph node metastasis was statistically assessed.
RESULTS: A positive cytoplasmic expression of VEGF-C was detected in both
epithelial and connective tissue cells in 97% of OSCC, while all normal tissues
reacted negatively. A greater expression of VEGF-C was associated with larger and
more dilated LV and lymph node metastasis but not with LVD. CONCLUSION: VEGF-C is
actively involved in the invasion and metastasis of OSCC via inducing
morphological changes in LV. VEGF-C may be a promising target for anticancer
therapy.