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10.1155/2017/6138145 http://scihub22266oqcxt.onion/10.1155/2017/6138145 C5478826!5478826 !28680883     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28680883 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Biomed+Res+Int 2017 ; 2017 (ä): 6138145 Nephropedia Template TP {{tp|p=28680883 |t=2017. The Interaction of Selectins and PSGL-1 as a Key Component in Thrombus Formation and Cancer Progression |pdf=|usr=}}{{28680883 }} gab.com Text The Interaction of Selectins and PSGL-1 as a Key Component in Thrombus Formation and Cancer Progression JO: Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=28680883 #FOAvip Cellular interaction is inevitable in the pathomechanism of human disease. Formation of heterotypic cellular aggregates, between distinct cells of hematopoietic and nonhematopoietic origin, may be involved in events leading to inflammation and the complex process of cancer progression. Among adhesion receptors, the family of selectins with their ligands have been considered as one of the major contributors to cell-cell interactions. Consequently, the inhibition of the interplay between selectins and their ligands may have potential therapeutic benefits. In this review, we focus on the current evidence on the selectins as crucial modulators of inflammatory, thrombotic, and malignant disorders. Knowing that there is promiscuity in selectin binding, we outline the importance of a key protein that serves as a ligand for all selectins. This dimeric mucin, the P-selectin glycoprotein ligand 1 (PSGL-1), has emerged as a major player in inflammation, thrombus, and cancer development. We discuss the interaction of PSGL-1 with various selectins in physiological and pathological processes with particular emphasis on mechanisms that lead to severe disease. Twit Text FOAVip The Interaction of Selectins and PSGL-1 as a Key Component in Thrombus Formation and Cancer Progression ????Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=28680883 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28680883 #FOAvip English Wikipedia <ref>{{Cite pmid|28680883 }}</ref> The Interaction of Selectins and PSGL-1 as a Key Component in Thrombus Formation and Cancer Progression #MMPMID28680883 Kappelmayer J ; Nagy B Jr Biomed Res Int 2017[]; 2017 (ä): 6138145 PMID28680883 show ga Cellular interaction is inevitable in the pathomechanism of human disease. Formation of heterotypic cellular aggregates, between distinct cells of hematopoietic and nonhematopoietic origin, may be involved in events leading to inflammation and the complex process of cancer progression. Among adhesion receptors, the family of selectins with their ligands have been considered as one of the major contributors to cell-cell interactions. Consequently, the inhibition of the interplay between selectins and their ligands may have potential therapeutic benefits. In this review, we focus on the current evidence on the selectins as crucial modulators of inflammatory, thrombotic, and malignant disorders. Knowing that there is promiscuity in selectin binding, we outline the importance of a key protein that serves as a ligand for all selectins. This dimeric mucin, the P-selectin glycoprotein ligand 1 (PSGL-1), has emerged as a major player in inflammation, thrombus, and cancer development. We discuss the interaction of PSGL-1 with various selectins in physiological and pathological processes with particular emphasis on mechanisms that lead to severe disease. |Animals [MESH] |Humans [MESH] |Membrane Glycoproteins/*metabolism [MESH] |Neoplasm Proteins/*metabolism [MESH] |Neoplasms/*metabolism/pathology [MESH] |Selectins/*metabolism [MESH]The Interaction of Selectins and PSGL-1 as a Key Component in Thrombus(epmc).pdf DeepDyve Pubget Overpricing