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10.22038/IJBMS.2017.8675 http://scihub22266oqcxt.onion/10.22038/IJBMS.2017.8675 C5478779!5478779!28656086     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Iran+J+Basic+Med+Sci 2017 ; 20 (5): 511-5 Nephropedia Template TP {{tp|p=28656086|t=2017. Berberine protects against metformin-associated lactic acidosis in induced diabetes mellitus |pdf=|usr=}}{{28656086}} gab.com Text Berberine protects against metformin-associated lactic acidosis in induced diabetes mellitus JO: Iran J Basic Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=28656086 #FOAvip Objective(s):: Causality of occurrence of metformin-associated lactic acidosis (MALA) is a clinical problem. Currently, there is no drug available to prevent MALA. The present study was conducted to evaluate the protective effect of Berberine (BBR) against MALA in induced diabetic rat model. Materials and Methods:: A sample of 75 healthy male Wistar rats was randomly selected according to inclusion and exclusion criteria. 75 male Wistar rats were randomly divided into a control and 4 experimental groups. Streptozotocin (STZ) in citrate buffer (pH 4.5) at a dose of 45 mg/kg was injected for induction of diabetes mellitus and rats achieving fasting blood glucose >250 mg/dl were included. Blood samples were collected 18 hr after the last dose of metformin and berberine. Ethical approval was taken before the study was conducted. Staistix 10.0 (USA) software was used for data analysis. Results:: Berberine decreased MALA. Metformin, metformin + BBR 50 mg/kg bwt, and metformin + BBR 100 mg/kg bwt showed serum lactate as 1.87±0.4 mmol/lL, 1.62 ± 0.44 mmol/l and 1.47± 0.45 mmol/l, respectively (P=0.0001). Insulin resistance and liver enzymes were improved in BBR treated rats. Conclusion:: The present study reports berberine protects against MALA in streptozocin-induced diabetes mellitus. Twit Text FOAVip Berberine protects against metformin-associated lactic acidosis in induced diabetes mellitus ????Iran J Basic Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=28656086 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28656086 #FOAvip English Wikipedia <ref>{{Cite pmid|28656086}}</ref> Berberine protects against metformin-associated lactic acidosis in induced diabetes mellitus #MMPMID28656086 Almani SA; Memon IA; Shaikh TZ; Khoharo HK; Ujjan I Iran J Basic Med Sci 2017[May]; 20 (5): 511-5 PMID28656086show ga Objective(s):: Causality of occurrence of metformin-associated lactic acidosis (MALA) is a clinical problem. Currently, there is no drug available to prevent MALA. The present study was conducted to evaluate the protective effect of Berberine (BBR) against MALA in induced diabetic rat model. Materials and Methods:: A sample of 75 healthy male Wistar rats was randomly selected according to inclusion and exclusion criteria. 75 male Wistar rats were randomly divided into a control and 4 experimental groups. Streptozotocin (STZ) in citrate buffer (pH 4.5) at a dose of 45 mg/kg was injected for induction of diabetes mellitus and rats achieving fasting blood glucose >250 mg/dl were included. Blood samples were collected 18 hr after the last dose of metformin and berberine. Ethical approval was taken before the study was conducted. Staistix 10.0 (USA) software was used for data analysis. Results:: Berberine decreased MALA. Metformin, metformin + BBR 50 mg/kg bwt, and metformin + BBR 100 mg/kg bwt showed serum lactate as 1.87±0.4 mmol/lL, 1.62 ± 0.44 mmol/l and 1.47± 0.45 mmol/l, respectively (P=0.0001). Insulin resistance and liver enzymes were improved in BBR treated rats. Conclusion:: The present study reports berberine protects against MALA in streptozocin-induced diabetes mellitus. äBerberine protects against metformin-associated lactic acidosis in ind(epmc).pdf DeepDyve Pubget Overpricing