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Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Intern+Med 2017 ; 56 (9): 1071-7 Nephropedia Template TP
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Multiple Gouty Tophi with Bone Erosion and Destruction: A Report of an Early-onset Case in an Obese Patient #MMPMID28458315
D Hayashi R; Yamaoka M; Nishizawa H; Fukuda S; Fujishima Y; Kimura T; Kozawa J; Kita S; Matsuoka Ta; Otsuki M; Imagawa A; Ichida K; Taniguchi A; Maeda N; Funahashi T; Shimomura I
Intern Med 2017[May]; 56 (9): 1071-7 PMID28458315show ga
A 27 year-old severely obese man (BMI, 35.1) had hyperuricemia and multiple gouty tophi with bone erosion and destruction, resulting in gait disturbance for 6 years after the early onset of gout at 21 years of age. His hyperuricemia was associated with hyperinsulinemia in obesity and a genetic variant of the ABCG2 gene. In addition, multiple gouty tophi with bone erosion and destruction might have been caused by hypoadiponectinemia and the elevation of the patient?s pro-inflammatory cytokine (IL-1?) level with the accumulation of visceral fat. In this case, bone and Ga-67 scintigraphy were useful for detecting the location and magnitude of gouty tophi.